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Effect of Overexpression of Protein Kinase Cα on Rat Lacrimal Gland Protein Secretion

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Book cover Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

Tears are a complex fluid, the components of which are secreted by several different glands and cell types. Tears are responsible for maintaining optimal concentrations of pH, osmolarity, ionic concentrations and proteins necessary for the function of the ocular surface.1,2 Thus, exquisite control of secretion of tears is required, and, when this control is compromised, disruption of the ocular surface and eventually ocular surface disease can occur.4 These ocular surface diseases include a range of tear-deficient disorders known as dry eye syndromes.

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References

  1. D. Lamberts, Physiology of the tear film, in: The Cornea, G. Smolin and R. Thoft, eds., Little, Brown and Company, Boston (1994).

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  2. D. Sullivan and E. Sato, Immunology of the lacrimal gland, in Principles and Practices of Ophthalmology: Basic Sciences, D. Albert, F. Jacobiec and N. Robinson, eds, WB Saunders, Philadelphia (1994).

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  3. J. Gilbard, S. Rossi, K. Gray, L. Hanninen, and K. Kenyon, Tear film osmolarity and ocular surface disease in two rabbit models for keratoconjunctivitis sicca, Invest Ophthalmol Vis Sci, 29:374 (1988).

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  4. D. Zoukhri, R. Hodges, C. Sergheraert, A. Toker, and D. Dartt, Lacrimal gland and PKC isoforms are differentially involved in agonist-induced protein secretion, Am J Physiol, 272:C263 (1997).

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Author information

Authors and Affiliations

  1. Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

    Robin R. Hodges, Andrius Kazlauskas & Darlene A. Dartt

  2. Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA

    Alex Toker

Authors
  1. Robin R. Hodges
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  2. Andrius Kazlauskas
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  3. Alex Toker
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  4. Darlene A. Dartt
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Hodges, R.R., Kazlauskas, A., Toker, A., Dartt, D.A. (2002). Effect of Overexpression of Protein Kinase Cα on Rat Lacrimal Gland Protein Secretion. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_32

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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