Skip to main content
SpringerLink
Log in

Effects of Preganglionic Parasympathetic Denervation on the Rabbit Lacrimation

  • Chapter
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

Lacrimal gland fluid secretion is under neural control. Parasympathetic nerve fibers, with preganglionic origins in the seventh cranial nerve, innervate the lacrimal gland, and the secretory action and signal transduction of acinar cells of this gland are well known.1–4 Although the importance of parasympathetic control of lacrimation is recognized, few basic studies have investigated the function of ganglionic control as a secretomotor neural system in secretion of tear fluid in vivo.5 In the present study, the effects of acute severing of the preganglionic parasympathetic nerve in normal rabbit produced a dry eye condition with rapid onset.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M.E. Stern, R.W. Beuerman, R.I. Fox, J. Gao, A.K. Mircheff, S.C. Pflugfelder. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–9 (1998).

    Article  CAS  PubMed  Google Scholar 

  2. Dartt DA. Regulation of tear secretion. Adv Exp Med Biol. 350:1–9 (1994).

    Article  CAS  PubMed  Google Scholar 

  3. S.L. Ruskin. Control of tearing by blocking the nasal ganglion. Arch Ophthalmol. 4:208–11 (1930).

    Article  Google Scholar 

  4. G.L. Ruskell. Changes in nerve terminals and acini of the lacrimal gland and changes in secretion induced by autonomic denervation. Z Zellforsch Mikrosk Anat. 94:261–81 (1969).

    Article  CAS  PubMed  Google Scholar 

  5. H. Toshida, R.W. Beuerman. Effects of pre-ganglionic, parasympathetic denervation on tear flow and goblet cell function in the rabbit Invest Ophthalmol Vis Sci. 41:s64 (2000).

    Google Scholar 

  6. O.P. van Bijsterveld. Diagnostic tests in the sicca syndrome. Arch Ophthalmol. 82:10–4 (1969).

    Article  PubMed  Google Scholar 

  7. R.W. Beuerman, L. Pedroza. Ultrastructure of human cornea. Microsc Res Tech. 33:320–335 (1996).

    Article  CAS  PubMed  Google Scholar 

  8. D. Maitchouk, R.W. Beuerman. Tear production after unilateral removal of the main lacrimal gland in squirrel monkeys. Arch Ophthalmol. 188:246–52 (2000).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lion’s Eye Research Laboratories, Laboratory for the Molecular Biology of the Ocular Surface, Louisiana State University Eye Center, New Orleans, Louisiana, USA

    Hiroshi Toshida & Roger W. Beuerman

Authors
  1. Hiroshi Toshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roger W. Beuerman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic/Plenum Publishers

About this chapter

Cite this chapter

Toshida, H., Beuerman, R.W. (2002). Effects of Preganglionic Parasympathetic Denervation on the Rabbit Lacrimation. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation