The Influence of Aging in the Insulin-Signaling System in Rat Exocrine Glands

  • Eduardo M. Rocha
  • Carla R. O. Carvalho
  • Mário J. A. Saad
  • Lício A. Velloso
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)


Aging is accompanied by morphological and secretory changes in lacrimal and salivary glands (LG and SG) that correlate with manifestations of dry eye and mouth among the elderly.1–6 Apart from systemic diseases, hormonal imbalances and the use of medications affect organ functions during aging.7 A concomitant impairment of the mechanisms of signal transduction may contribute to specific organ dysfunction.8–10


Respiratory Syncytial Virus Herpes Simplex Virus Type Corneal Epithelial Cell Corneal Stroma Chemokine Expression 
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  1. 1.
    B.B. Bromberg, M. Welch. Lacrimal protein secretion: comparison of young and old rats. Exp Eye Res. 40:313–320 (1985).CrossRefPubMedGoogle Scholar
  2. 2.
    J. McGill, G. Liakos, N. Goulding, DV Seal. Normal tear protein profiles and age-related changes. Br J Ophthalmol. 68:316–320 (1984).CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    L.M. Sreebny, A. Valdini, A. Yu, S. Brook. Xerostomia. Part I: relationship to other oral symptoms and salivary gland hypofunction. Oral Surg Oral Med Oral Pathol. 6:451–458 (1988).CrossRefGoogle Scholar
  4. 4.
    A. Vissink, F.K.L. Spijkervet, A.V.N. Amerongen. Aging and saliva: a review of the literature. Spec Care Dentist. 16:95–103 (1996).CrossRefPubMedGoogle Scholar
  5. 5.
    W.D. Mathers, J.A. Lane, M.B. Zimmerman. Tear film changes associated with normal aging. Cornea. 15:229–334 (1996).CrossRefPubMedGoogle Scholar
  6. 6.
    O.D. Schein, B. Muñoz, J.M. Tielsch, K. Badeen-Roche, S. West. Prevalence of dry eye among the elderly. Am J Ophthalmol. 124:723–728 (1997).CrossRefPubMedGoogle Scholar
  7. 7.
    L.M. Sreebny, A. Valdini, A. Yu, S. Brook. Xerostomia. Part II: Relationship to nonoral symptoms, drugs, and diseases. Oral Surg Oral Med Oral Pathol. 68:419–427 (1989).CrossRefPubMedGoogle Scholar
  8. 8.
    G. Wortwëin, J. Yu, T. Toliver-Kinsky, J. R. Perez-Polo. Responses of young and aged rat CNS to partial cholinergic immunolesions and NGF treatment. J Neurosci Res. 52:322–333 (1998).CrossRefPubMedGoogle Scholar
  9. 9.
    T. Ishizuca, M. Yamamoto, K. Kajita, K. Yasuda, K. Miura, H. Hernandez, R.V. Farese. Differential effect of aging on protein kinase C activity in rat adipocytes and soleus muscle. Metabolism. 42:420–425 (1993).CrossRefGoogle Scholar
  10. 10.
    M.E. Bach, M. Barad, H. Son, M. Zhuo, Y. Lu, R. Shih, I. Mansuy, R.D. Hawkins, E.R. Kandel. Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc Natl Acad Sci USA. 96:5280–5285 (1999).CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    C.R.O. Carvalho, S.L. Brenelli L, A.C. Silva, A.L.B. Nunes, L.A. Velloso, M.J.A. Saad. Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats. Endocrinology. 37:151–159 (1996).CrossRefGoogle Scholar
  12. 12.
    E.V. Páez-Espinosa, E.M. Rocha, L.A. Velloso, A.C. Boschero, M.J.A. Saad. Regulation of insulin-induced tyrosine phosphorylation of Shc and Shc-GRB2 association in liver, muscle and adipose tissue in insulin resistant rats. Mol Cel Endocrinol.; 156:121–129 (1999).CrossRefGoogle Scholar
  13. 13.
    E.M. Rocha, M.H.M. Lima, C.R.O. Carvalho, M.J.A. Saad A, L.A. Velloso. Characterization of the insulin signaling pathway in lacrimal and salivary glands of rats. Curr Eye Res. 21:833–842 (2000).CrossRefPubMedGoogle Scholar
  14. 14.
    E.M. Rocha, Saad MJA, L.A. Velloso. The Influence of Aging in the Initial Steps of the Insulin Signaling System in Rat Exocrine Glands. Submitted, 2000.Google Scholar
  15. 15.
    L.E. Hann, R.S. Kelleher, D.A. Sullivan. Influence of culture conditions on the androgen control of secretory component production by acinar cells from the lacrimal gland. Invest Ophthalmol Vis Sci. 32:2610–2621 (1991).PubMedGoogle Scholar
  16. 16.
    D.A. Sullivan, L.E. Hann, L. Yee, M.R. Allansmith. Age- and gender-related influence on the lacrimal gland and tears. Acta Ophthalmol (Copenh). 68:188–194 (1990).CrossRefGoogle Scholar
  17. 17.
    M.J.A. Saad. Molecular mechanisms of insulin resistance. Braz J Med Biol Res. 27:941–957 (1994).PubMedGoogle Scholar
  18. 18.
    L. Frölich, D. Blum-Degen, H.G. Bernstein, S. Engelsberger, J. Humrich, S. Laufer, D. Muschner, A. Thalheimer, A. Türk, S. Hoyer, R. Zöchling, K.W. Boissl, K. Jellinger, P. Riederer. Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease. J Neural Transm. 105:423–438 (1998).CrossRefPubMedGoogle Scholar
  19. 19.
    S. Kono, H. Kuzuya, M. Okamoto, H. Nishimura, A. Kosaki, T. Kjakehi, G. Inove, I. Maeda, H. Imura. Changes in receptor kinase with aging in rat skeletal muscle and liver. Am J Physiol.; 254:E27–E35 (1998).Google Scholar
  20. 20.
    J.M. Carrascosa, P. Ruiz, C. Martinez, J.A. Pulido, J. Satrustegui, A. Andres. Insulin receptor kinase activity in rat adipocytes is decreased during aging. Biochem Biophys Res Commun.; 160:303–309 (1989).CrossRefPubMedGoogle Scholar
  21. 21.
    X. Xu, W.E. Sonntag. Growth hormone-induced nuclear translocation of STAT-3 decreases with age: modulation by caloric restriction. Am J Physiol. 34:E903–E909 (1996).Google Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Eduardo M. Rocha
    • 1
  • Carla R. O. Carvalho
    • 2
  • Mário J. A. Saad
    • 1
  • Lício A. Velloso
    • 1
  1. 1.Laboratory of Clinical Physiopathology, Department of Clinical MedicineFCM-UNICAMPCampinasBrazil
  2. 2.Department of PhysiologyICB-USPSão PauloBrazil

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