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Immunolocalization and Physiological Effect of Serotonin in the Porcine Lacrimal Gland

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

The lacrimal gland produces the bulk of the tear film that covers the external surface of the cornea and ensures that the corneal epithelium is kept moist and transparent. The transparency of the cornea is a prerequisite for normal refraction of light. The lacrimal gland is innervated by a branch of the ophthalmic division of the trigeminal nerve.1 The nerve supply of the lacrimal gland consists of afferent and efferent pathways involving both the sympathetic and parasympathetic divisions of the nervous system. It has been shown that neurotransmitters and neuropeptides are present in the nerves innervating the lacrimal gland of various mammalian species.2, 3 The aim of this study was to examine the effect of serotonin (5-HT) on total protein, peroxidase and magnesium released from pig lacrimal gland fragments. The immunolocalization of 5-HT in the porcine lacrimal glands was investigated using immunohistochemical techniques.

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References

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Author information

Authors and Affiliations

  1. Department of Human Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates

    Ernest Adeghate

  2. Department of Biological Sciences, University of Central Lancashire, Preston, England, UK

    Benjamin Zumbrunn & Jaipaul Singh

Authors
  1. Ernest Adeghate
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  2. Benjamin Zumbrunn
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  3. Jaipaul Singh
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Adeghate, E., Zumbrunn, B., Singh, J. (2002). Immunolocalization and Physiological Effect of Serotonin in the Porcine Lacrimal Gland. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_29

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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