Immunolocalization and Physiological Effect of Serotonin in the Porcine Lacrimal Gland

  • Ernest Adeghate
  • Benjamin Zumbrunn
  • Jaipaul Singh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)


The lacrimal gland produces the bulk of the tear film that covers the external surface of the cornea and ensures that the corneal epithelium is kept moist and transparent. The transparency of the cornea is a prerequisite for normal refraction of light. The lacrimal gland is innervated by a branch of the ophthalmic division of the trigeminal nerve.1 The nerve supply of the lacrimal gland consists of afferent and efferent pathways involving both the sympathetic and parasympathetic divisions of the nervous system. It has been shown that neurotransmitters and neuropeptides are present in the nerves innervating the lacrimal gland of various mammalian species.2, 3 The aim of this study was to examine the effect of serotonin (5-HT) on total protein, peroxidase and magnesium released from pig lacrimal gland fragments. The immunolocalization of 5-HT in the porcine lacrimal glands was investigated using immunohistochemical techniques.


High Performance Liquid Chromatography Polar Lipid Contact Lens Cholesterol Ester Lipid Layer 
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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Ernest Adeghate
    • 1
  • Benjamin Zumbrunn
    • 2
  • Jaipaul Singh
    • 2
  1. 1.Department of Human Anatomy, Faculty of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates
  2. 2.Department of Biological SciencesUniversity of Central LancashirePrestonEngland, UK

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