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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3 pp 19–26Cite as

GDNF Family Signalling in Exocrine Tissues: Distinct Roles for GDNF and Neurturin in Parasympathetic Neuron Development

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

Glial cell line-derived neurotrophic factor (GDNF) and related neurotrophic factors neurturin (NRTN), artemin (ARTN) and persephin (PSPN) form a subgroup in the transforming growth factor-β superfamily. They signal by binding to a receptor complex consisting of a ligand-binding GPI-anchored GDNF family receptor a (GFRα1 to GFRα4) and the trans-membrane tyrosine kinase Ret (for review see references 1–3). A schematic view of the GDNF family signaling is shown in Fig. 1.

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Authors and Affiliations

  1. Program in Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland

    Jari Rossi & Matti S. Airaksinen

Authors
  1. Jari Rossi
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  2. Matti S. Airaksinen
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Rossi, J., Airaksinen, M.S. (2002). GDNF Family Signalling in Exocrine Tissues: Distinct Roles for GDNF and Neurturin in Parasympathetic Neuron Development. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_2

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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