Androgen Influence on Lymphocyte Gene Expression
Sjögren’s syndrome is an insidious and currently incurable autoimmune disorder occurring primarily in women, and associated with an extensive lymphocyte accumulation in the lacrimal gland, an immune-mediated destruction and/or dysfunction of acinar and ductal epithelial cells, a precipitous decrease in tear secretion and severe dry eye.1,2 Recently, we discovered that androgen administration to the female MRL/Mp-lpr/lpr (MRL/lpr) and NZB/NZW F1 mouse models of Sjögren’s syndrome causes a dramatic suppression of the inflammation in, and a significant increase in the functional activity of, lacrimal glands.3 However, the precise mechanism(s) underlying this hormone action is unknown.
KeywordsLamina Propria Germinal Center Ocular Surface Lacrimal Gland Nasolacrimal Duct
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