Androgen Influence on Lymphocyte Gene Expression
Sjögren’s syndrome is an insidious and currently incurable autoimmune disorder occurring primarily in women, and associated with an extensive lymphocyte accumulation in the lacrimal gland, an immune-mediated destruction and/or dysfunction of acinar and ductal epithelial cells, a precipitous decrease in tear secretion and severe dry eye.1,2 Recently, we discovered that androgen administration to the female MRL/Mp-lpr/lpr (MRL/lpr) and NZB/NZW F1 mouse models of Sjögren’s syndrome causes a dramatic suppression of the inflammation in, and a significant increase in the functional activity of, lacrimal glands.3 However, the precise mechanism(s) underlying this hormone action is unknown.
KeywordsFormaldehyde Germinal Paraffin Microbe Hematoxylin
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- 1.Sullivan DA, Wickham LA, Krenzer KL, Rocha EM, Toda I. Aqueous tear deficiency in Sjögren’s syndrome: possible causes and potential treatment. In: Pleyer U, Hartmann C, Sterry W, eds. Oculodermal Diseases — Immunology of Bullous Oculo-Muco-Cutaneous Disorders. Buren, The Netherlands: Aeolus Press, 1997:95–152.Google Scholar
- 2.Homma M, Sugai S, Tojo T, Miyasaka N, Akizuki M, editors. Sjögren’s Syndrome. State of the Art. Amsterdam: Kugler Press, 1994.Google Scholar
- 3.Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R, Cermak JM, Dana MR, Ullman MD, Sato EH, Gao J, Rocha FJ, Ono M, Silveira LA, Lambert RW, Kelleher RS, Tolls BD, Toda I. Androgens and dry eye in Sjögren’s syndrome. Ann NY Acad Sci. 1999; 876:312–324.CrossRefPubMedGoogle Scholar
- 4.Richards SM, Sullivan BD, Liu M, Sullivan D. Effect of gender on gene expression in the mouse lacrimal gland. Manuscript submitted, 2001.Google Scholar
- 5.Nelson N, Kanno Y, Hong C, Contursi C, Fujita T, Fowlkes BJ, O’Connell E, Hu-Li J, Paul WE, Jankovic D, Sher AF, Coligan JE, Thornton A, Appella E, Yang Y, Ozato K. Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation. J Immunol. 1996; 156:3711–3720.PubMedGoogle Scholar
- 13.Sullivan DA. Sex hormones and Sjögren’s syndrome. J Rheumatol. 1997; 24 (Suppl 50): 17–32.Google Scholar