Androgen Influence on Lymphocyte Gene Expression

  • W. R. Bijlsma
  • B. A. R. Tonino
  • S. M. Richards
  • M. Liu
  • B. D. Sullivan
  • D. A. Sullivan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)


Sjögren’s syndrome is an insidious and currently incurable autoimmune disorder occurring primarily in women, and associated with an extensive lymphocyte accumulation in the lacrimal gland, an immune-mediated destruction and/or dysfunction of acinar and ductal epithelial cells, a precipitous decrease in tear secretion and severe dry eye.1,2 Recently, we discovered that androgen administration to the female MRL/Mp-lpr/lpr (MRL/lpr) and NZB/NZW F1 mouse models of Sjögren’s syndrome causes a dramatic suppression of the inflammation in, and a significant increase in the functional activity of, lacrimal glands.3 However, the precise mechanism(s) underlying this hormone action is unknown.


Lamina Propria Germinal Center Ocular Surface Lacrimal Gland Nasolacrimal Duct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • W. R. Bijlsma
    • 1
  • B. A. R. Tonino
    • 1
  • S. M. Richards
    • 1
  • M. Liu
    • 1
  • B. D. Sullivan
    • 1
  • D. A. Sullivan
    • 1
  1. 1.Schepens Eye Research Institute and the Department of OphthalmologyHarvard Medical SchoolBostonUSA

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