Identification of Androgen-Regulated Genes in the Lacrimal Gland
Androgens exert a significant influence on the cellular architecture, protein synthesis, immune function and secretory activity of the lacrimal gland.1 In fact, these hormone effects appear to account for many of the gender-related differences that occur in the anatomy, biochemistry, physiology and immunology of lacrimal tissue in a variety of species.1 We hypothesize that androgen actions are mediated primarily through androgen receptors, which exist in lacrimal gland epithelial cells,2–4 and involve the regulation of specific target genes. The purpose of this investigation was to identify the genes controlled by androgens in lacrimal tissue.
KeywordsContact Lens Wearer Oral Immunization Acanthamoeba Keratitis Corneal Infection Intramuscular Immunization
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- 7.Liu M, Richards SM, Schirra F, Yamagami H, Sullivan BD, Sullivan DA. Androgen regulation of gene expression in the lacrimal gland. Manuscript submitted, 2001.Google Scholar
- 8.Richards SM, Sullivan BD, Liu M, Sullivan D. Effect of gender on gene expression in the mouse lacrimal gland. Manuscript submitted, 2001.Google Scholar