Striatal Tans do not Report Prediction Error
The main cortical input structure of the basal ganglia, the striatum, is also the main domain of action of two extremely powerful modulators of neuronal transmission, as indicated by density of their respective markers - dopamine and acetylcholine (Parent et al., 1995; Gerfen and Wilson, 1996). The close interaction and similarity of function between the two substances in the basal ganglia has been widely stressed in the past. It is becoming increasingly evident that normal performance of the basal ganglia requires a delicate balance of the two substances. Symptoms of Parkinson’s disease, the main pathological finding of which is degeneration of the dopamine systems, are alleviated by pharmacological administration of anti-cholinergic agents (Barbeau, 1962). Both dopamine and acetylcholine have been shown to modulate cortico-striatal transmission in a temporally precise manner (Kerr and Wickens. 2001; Calabresi et al., 2000; Centonze et al., 1999). It is therefore almost natural to consider both the dopamine and acetylcholine striatal systems as one.
KeywordsDopamine Tungsten Acetylcholine Ketamine Cote
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