Advertisement

Discharge Properties of Group III and IV Muscle Afferents

  • Marc P. Kaufman
  • Shawn G. Hayes
  • Christine M. Adreani
  • Joel G. Pickar
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 508)

Abstract

Stimulation of group III and IV muscle afferents has been shown to have important reflex effects on both the somatic and autonomic nervous systems. These include an inhibitory effect on alpha motoneurones, an excitatory effect on gamma motoneurones and an excitatory effect on the sympathetic nervous system. The purpose of this review is to describe the mechanical and metabolic stimuli that discharge group III and IV muscle afferents. Particular attention will be paid to the responses of these afferents to dynamic exercise induced by electrical stimulation of the mesencephalic locomotor region.

Keywords

Apply Physiology Discharge Property Dynamic Exercise Muscle Afferents Gadolinium Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abrahams, V. C., Lynn, B., and Richmond, F. J. R., 1984, Organization and sensory properties of small myelinated fibres in the dorsal cervical rami of the catJournal of Physiology347, 177–187.PubMedGoogle Scholar
  2. Adreani, C. M., Hill, J. M., and Kaufman, M. P., 1997, Responses of group III and IV muscle afferents to dynamicexercise Journal of Applied Physiology86, 1811–1817.Google Scholar
  3. Adreani, C. M., and Kaufman, M. P., 1998, Effect of arterial occlusion on responses of group III and IV afferents to dynamic exerciseJournal of Applied Physiology84(6), 1827–1833.PubMedGoogle Scholar
  4. Bessou, P., and LaPorte, Y., 1958, Activation des fibres afférentes amyélinisées de petit calibre, d’origine musculaire (fibre du groupe Ill)Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales1521587–1590. PubMedGoogle Scholar
  5. Bockman, E. L., 1983, Blood flow and oxygen consumption in active soleus and gracilis muscles in catsAmerican Journal of Physiology244546–551.Google Scholar
  6. Ellaway, P. H., Murphy, P. R., and Tripathi, A., 1982, Closely coupled excitation of gamma-motoneurons by group III muscle afferents with low mechanical threshold in a catJournal of Physiology331, 481–498.PubMedGoogle Scholar
  7. Graham, R., Jammes, Y., Delpierre, S., Grimaud, C., and Roussos, Ch., 1986, The effects of ischemia, lactic acid and hypertonic sodium chloride on phrenic afferent discharge during spontaneous diaphragmatic contractionNeuroscience Letters67, 257–262.PubMedCrossRefGoogle Scholar
  8. Hayes, S., and Kaufman, M. P., 2001, Gadolinium attenuates exercise pressor reflex in catsAmerican Journal of Physiology280, H2153–H2161.PubMedGoogle Scholar
  9. Hayward, L., Breitbach, D., and Rymer, W. Z., 1988, Increased inhibitory effects on close synergists during muscle fatigue in the decerebratecat Brain Research440, 199–203.PubMedCrossRefGoogle Scholar
  10. Hayward, L., Wesselmann, U., and Rymer, W. Z., 1991, Effects of muscle fatigue on mechanically sensitive afferents of slow conduction velocity in the cat triceps suraeJournal of Neurophysiology65, 360–370.PubMedGoogle Scholar
  11. Henneman, E., Somjen, G., and Carpenter, D. O., 1965, Functional significance of cell size in spinal motoneuronsJournal of Neurophysiology28, 560–580.PubMedGoogle Scholar
  12. Hník, P., Hudlická, O., Kucera, J., and Payne, R., 1969, Activation of muscle afferents by nonproprioceptive stimuliAmerican Journal of Physiology217, 1451–1458.PubMedGoogle Scholar
  13. Hoffer, J. A., Loeb, G. E., Marks, W. B., O’Donovan, M. J., Pratt, C. A., and Sugano, N., 1987a, Cat hind limb motoneurons during locomotion. I. Destination, axonal conduction velocity, and recruitment thresholdJournal of Neurophysiology57, 510–529.Google Scholar
  14. Hoffer, J. A., O’Donovan, M. J., Pratt, C. A., and Loeb, G. E., 1981, Discharge patterns of hindlimb motoneurons during normal cat locomotionScience213, 466–468.PubMedCrossRefGoogle Scholar
  15. Hoffer, J. A., Sugano, N., Loeb, G. E., Marks, W. B., O’Donovan, M. J., and Pratt, C. A., 1987b, Cat hind limb motoneurons during locomotion. II. Normal activity patternsJournal of Neurophysiology57, 530–553.Google Scholar
  16. Iggo, A., 1961, Non-myelinated afferent fibers from mammalian skeletal muscleJournal of hysiology155, 52–53.Google Scholar
  17. Jovanovic, K., Anastasijevic, R., and Vuco, J., 1990, Reflex effects on gamma fusimotor neurones of chemically induced discharges in small diameter muscle afferents in decerebrate catsBrain Research521,89–94.PubMedCrossRefGoogle Scholar
  18. Kaufman, M. P., and Forster, H. V., 1996, Reflexes controlling circulatory, ventilatory and airway responses to exercise. In ‘Handbook of Physiology, Section 12: Exercise: Regulation and Integration of Multiple Systems. II. Control of Respiratory and Cardiovascular Systems’, L. B. Rowell and J. T. Shepherd, eds., Oxford University Press, New York, pp. 381–447.Google Scholar
  19. Kaufman, M. P., Longhurst, J. C., Rybicki, K. J., Wallach, J. H., and Mitchell, J. H., 1983, Effects of static muscular contraction on impulse activity of groups III and IV afferents in catsJournal. of Applied Physiology 55,105–112.PubMedGoogle Scholar
  20. Kaufman, M. P., and Rybicki, K. J., 1987, Discharge properties of group III and IV muscle afferents: their responses to mechanical and metabolic stimuliCirculation Research61, 160–165.Google Scholar
  21. Kaufman, M. P., Rybicki, K. J., Waldrop, T. G., and Ordway, G. A., 1984a, Effect of ischemia on responses of group III and IV afferents to contractionJournal of Applied Physiology57, 644–650.Google Scholar
  22. Kaufman, M. P., Rybicki, K. J., Waldrop, T. G., Ordway, G. A., and Mitchell, J. H., 1984b, Effects of static and rhythmic twitch contractions on the discharge of group III and IV muscle afferentsCardiovascular Research18,663–668.CrossRefGoogle Scholar
  23. Kenagy, J., VanCleave, J., Pazdemik, L., and Orr, J. A., 1997, Stimulation of group III and Iv afferent nerves from the hindlimb by thromboxane A2Brain Research744, 175–178.PubMedCrossRefGoogle Scholar
  24. Kniffki, K.-D., Mense, S., and Schmidt, R. F., 1978, Responses of group IV afferent units from skeletal muscle to stretch, contraction and chemical stimuliExperimental Brain Research31, 511–522.CrossRefGoogle Scholar
  25. Kumazawa, T. N., and Mizumura, K., 1977, Thin-fibre receptors responding to mechanical, chemical and thermal stimulation in the skeletal muscle of the dogJournal of Physiology273, 179–194.PubMedGoogle Scholar
  26. Mense, S., 1977, Nervous outflow from skeletal muscle following chemical noxious stimulationJournal of Physiology267, 75–88.PubMedGoogle Scholar
  27. Mense, S., 1981, Sensitization of group IV muscle receptors to bradykinin by 5-hydroxytryptamine and prostaglandin E-2Brain Research225, 95–105.PubMedCrossRefGoogle Scholar
  28. Mense, S., and Meyer, H., 1988, Bradykinin-induced modulation of the response behavour of different types of feline group Ill and IV muscle receptorsJournal of Physiology398, 49–63.PubMedGoogle Scholar
  29. Mense, S. and Schmidt, R. F., 1974, Activation of group W afferent units from muscle by algesic agentsBrain Research72,305–310.PubMedCrossRefGoogle Scholar
  30. Mense, S., and Stahnke, M., 1983, Responses in muscle afferent fibers of slow conduction velocity to contractions and ischemia in the catJournal of Physiology342, 383–397.PubMedGoogle Scholar
  31. Paintal, A. S., 1960, Functional analysis of group III afferent fibres of mammalian musclesJournal of Physiology152, 250–270.PubMedGoogle Scholar
  32. Pickar, J. G., Hill, J. M., and Kaufman, M. P., 1994, Dynamic exercise stimulates group Ill muscle afferentsJournal of Neurophysiology71, 753–760.PubMedGoogle Scholar
  33. Rotto, D. M., Hill, J. M., Schultz, H. D., and Kaufman, M. P., 1990a, Cyclooxygenase blockade attenuates the responses of group IV muscle afferents to static contractionAmerican Journal of Physiology259, 745–750.Google Scholar
  34. Rotto, D. M., and Kaufman, M. P., 1988, Effects of metabolic products of muscular contraction on the discharge of group III and IV afferentsJournal of Applied Physiology64, 2306–2313.PubMedGoogle Scholar
  35. Rotto, D. M., Schultz, H. D., Longhurst, J. C., and Kaufman, M. P., 1990b, Sensitization of group III muscle afferents to static contraction by products of arachidonic acid metabolismJournal of Applied Physiology68,861–867.Google Scholar
  36. Rybicki, K. J., Waldrop, T. G., and Kaufman, M. P., 1985, Increasing gracilis interstitial potassium concentrations stimulates group Ill and IV afferentsJournal of Applied Physiology58, 936–941.PubMedCrossRefGoogle Scholar
  37. Shik, M. L., and Orlovsky, G. N., 1966, Locomotion of the diencephalic cat elicited by stimulation of the pyramidsBiofizika13, 143–152.Google Scholar
  38. Sinoway, L. I., Hill, J. M., Pickar, J. G., and Kaufman, M. P., 1993, Effects of contraction and lactic acid on the discharge of group Ill muscle afferents in catsJournal of Neurophysiology69, 1053–1059.PubMedGoogle Scholar
  39. Thimm, F., and Baum, K., 1987, Response of chemosensitive nerve fibers of group III and IV to metabolic changes in rat musclesPflügers Archives410, 143–152.CrossRefGoogle Scholar
  40. Wetzel, M. C., and Stuart, D. G., 1976, Ensemble characteristics of cat locomotion and its neural controlProgress in Neurobiology7, 1–98.PubMedCrossRefGoogle Scholar
  41. Zajac, F. E., and Faden, J. S., 1985, Relationship among recruitment order, axonal conduction velocity and muscle-unit properties of type-identified motor units in cat plantans muscleJournal of Neurophysiology53,1303–1322.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Marc P. Kaufman
  • Shawn G. Hayes
  • Christine M. Adreani
  • Joel G. Pickar
    • 1
  1. 1.Division of Cardiovascular Medicine, Departments of Internal Medicine and Human PhysiologyUniversity of CaliforniaDavisUSA

Personalised recommendations