A Cervical Propriospinal System in Man

  • Emmanuel Pierrot-Deseilligny
  • Véronique Marchand-Pauvert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 508)


Peripheral stimuli facilitate, at a pre-motoneuronal level, the responses elicited in human upper limb motoneurons (MNs) by transcranial magnetic stimulation over the motor cortex (TMS). Several features indicate that the ‘relevant premotoneurones are distinct from segmental interneurones and located rostra] to MNs. Thus, corticospinal volleys would have an indirect (propriospinal) pathway to upper limb MNs, in addition to the direct cortico-motoneuronal pathway. Slightly increasing the corticospinal input causes the facilitation to be reversed to inhibition. This is consistent with a well-developed system of inhibitory intemeurones activated by corticospinal and afferent inputs inhibiting propriospinal neurones (PNs). Corticospinal activation of these inhibitory intemeurones would explain why propriospinally-mediated corticospinal EPSPs are weak in primate MNs after artificial (electrical or magnetic) activation of the corticospinal system by itself. However, indirect evidence for descending facilitation of PNs can be provided during normal voluntary contractions, while using the modulation of the ongoing EMG or of the H reflex.


Transcranial Magnetic Stimulation Flexor Digitorum Superficialis Transcranial Magnetic Stimulation Intensity Combine Stimulation Separate Stimulus 
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  1. Alstermark, B., lsa, T., Ohki, T., and Saito, T., 1999, Di synaptic pyramidal excitation in forelimb motoneurons mediated via C3–C4 propriospinal neurons in theMacaca Fuscata Journal of Neurophysiology 82, 3580–3585.PubMedGoogle Scholar
  2. Burke, D., Gracies, J. M., Mazevet, D., Meunier, S., and Pierrot-Deseilligny, E., 1992, Convergence of descending and various peripheral inputs onto common propriospinal-like neurones in manJournal of Physiology449, 655–671.PubMedGoogle Scholar
  3. Burke, D., Gracies, J. M., Mazevet, D., Meunier, S., and Pierrot-Deseilligny, E., 1994, Non monosynaptic transmission of the cortical command for voluntary movement in manJournal of Physiology480, 191–202.PubMedGoogle Scholar
  4. Lundberg, A., 1999, Descending control of forelimb movements in thecat Brain Research Bulletin50, 323–324.PubMedCrossRefGoogle Scholar
  5. Maertens de Noordhout, A., Rapisarda, G., Bogacz, D., Gerard, P., De Pasqua, V., Pennisi, G., and Delwaide, P. J., 1999, Corticomotoneuronal synaptic connections in normal man. An electrophysiological studyBrain122, 1327–1340.CrossRefGoogle Scholar
  6. Maier, M. A., Illert, M., Kirkwood, P. A., Nielsen, J., and Lemon R. N., 1998, Does a C3–C4 propriospinal system transmit corticospinal excitation in the primate? An investigation in the macaque monkeyJournal of Physiology511, 191–212.PubMedCrossRefGoogle Scholar
  7. Mazevet, D., and Pierrot-Deseilligny, E., 1994, Pattern of descending excitation of presumed propriospinal neurones at the onset of voluntary movement in manActa Physiologica Scandinavica, 150, 27–38.CrossRefGoogle Scholar
  8. Nakajima, K., Maier, M. A., Kirkwood, P. A., and Lemon R. N., 2000, Striking differences in transmission of corticospinal excitation to upper limb motoneurons in two primate speciesJournal of Neurophysiology84, 698–709.PubMedGoogle Scholar
  9. Nicolas, G., Marchand-Pauvert, V., Burke, D., and Pierrot-Deseilligny, E., 2001,Corticospinal excitation of presumed propriospinal neurones and its reversal to inhibition in humansJournal of Physiology533, 903–919.PubMedCrossRefGoogle Scholar
  10. Pauvert, V., Pierrot-Deseilligny, E., and Rothwell, J. C., 1998, Role of spinal premotoneurones in mediating corticospinal input to forearm motoneurones in manJournal of Physiology508, 301–312.PubMedCrossRefGoogle Scholar
  11. Pierrot-Deseilligny, E., 1996, Transmission of the cortical command for human voluntary movement through cervical premotoneuronesProgress in Neurobiology48, 489–517.PubMedCrossRefGoogle Scholar
  12. Pierrot-Deseilligny, E., Morin, C., Bergego, C., and Tankov, N., 1981, Pattern of group I fibre projections from ankle flexor and extensor muscles in manExperimental Brain Research42, 337–350.Google Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Emmanuel Pierrot-Deseilligny
  • Véronique Marchand-Pauvert
    • 1
  1. 1.Neurophysiologie CliniqueRééducation, La SalpêtriéreParis, Cedex 13France

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