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Functional Properties of Primate Spinal Interneurones During Voluntary Hand Movements

  • Eberhard E. Fetz
  • Steve I. Perlmutter
  • Yifat Prut
  • Kazuhiko Seki
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 508)

Abstract

The activity of cervical spinal interneurones (INs) was recorded in monkeys performing alternating hand movements. The contribution of INs to voluntary movement was determined by their response patterns during ramp-and-hold wrist movements and their postspike effects on forelimb muscle activity. Most INs were active during both flexion and extension, in contrast to the unidirectional activity of muscles and corticomotoneuronal cells. When recorded during performance of an instructed delay task, the activity of many INs was modulated during the delay period between the instruction cue and the subsequent go signal. Thus, spinal INs, like cortical neurones, participate in earliest stages of preparation for movement. The modulation of peripheral input to spinal INs was tested during an instructed delay task. The monosynaptic responses to electrical stimulation of a cutaneous nerve decreased during active movement, probably due to presynaptic inhibition. These results provide new insights into the role of spinal INs in preparation and execution of voluntary movement.

Keywords

Delay Period Wrist Movement Primary Afferent Depolarization Muscle Field Nerve Cuff 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baldissera, F., Hultbom, H., and Illert, M., 1981, Integration in spinal neuronal systems, inHandbook of Physiology Section 1: The Nervous System; Volume II: Motor Control Part 2, American Physiological Society, Bethesda, MD, pp. 509–595.Google Scholar
  2. Cheney, P. D., Fetz, E. E., and Mewes, K., 1991, Neural mechanisms underlying corticospinal and rubrospinal control of limb movementsProgress in Brain Research87, 213–252.PubMedCrossRefGoogle Scholar
  3. Fetz, E. E., Perlmutter, S. I., and Prut, Y., 2000, Functions of mammalian spinal interneurons during movementCurrent Opinion in Neurobiology10, 699–707.PubMedCrossRefGoogle Scholar
  4. Flament, D., Fortier, P. A., and Fetz, E. E., 1992. Response patterns and post-spike effects of peripheral afferents in dorsal root ganglia of behaving monkeysJournal of Neurophysiology67, 875–889.PubMedGoogle Scholar
  5. Jankowska, E., 1992, Interneuronal relay in spinal pathways from proprioceptorsProgress in Neurobiology38, 335–378.PubMedCrossRefGoogle Scholar
  6. Kasser, R. J., and Cheney, P. D., 1985, Characteristics of corticomotoneuronal postspike facilitation and reciprocal suppression of EMG activity in the monkeyJournal of Neurophysiology53, 959–978.PubMedGoogle Scholar
  7. Maier, M. A., Perlmutter, S. I., and Fetz, E. E., 1998, Response patterns and force relations of monkey spinal interneurons during active wrist movementJournal of Neurophysiology80, 2495–2513.PubMedGoogle Scholar
  8. Mewes, K., and Cheney, P. D., 1994, Primate rubromotoneuronal cells: parametric relations and contribution to wrist movementJournal of Neurophysiology72, 14–30.PubMedGoogle Scholar
  9. Palmer, S. S., and Fetz, E. E., 1985, Discharge properties of primate forearm motor units during isometric muscle activityJournal of Neurophysiology54, 1178–1193.PubMedGoogle Scholar
  10. Perlmutter, S. I., Maier, M. A., and Fetz, E. E., 1998, Activity and output linkages of spinal premotor interneurons during voluntary wrist movements in the monkeyJournal of Neurophysiology80, 2475–2494.PubMedGoogle Scholar
  11. Perlmutter, S. I., and Prut, Y., 2001, Transformation of descending commands into muscle activity by spinal interneurons in behaving primates, in:Motor Neurobiology of the Spinal CordT. C. Cope, ed., CRC Press pp. 193–213Google Scholar
  12. Prut, Y., and Fetz, E. E., 1999, Primate spinal interneurons show pre-movement instructed delay activityNature401, 590–594.PubMedCrossRefGoogle Scholar
  13. Wall, P. D., 1958, Excitability changes in afferent fibre terminations and their relation to slow potentialsJournal of Physiology142, 1–21.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Eberhard E. Fetz
  • Steve I. Perlmutter
  • Yifat Prut
  • Kazuhiko Seki
    • 1
  1. 1.Department of Physiology & Biophysics and Regional Primate Research CenterUniversity of WashingtonSeattleUSA

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