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Mechanisms Causing Plateau Potentials in Spinal Motoneurones

  • Aidas Alaburda
  • Jean-François Perrier
  • Jørn Hounsgaard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 508)

Abstract

Plateau potentials are generated by a voltage sensitive persistent inward current. In spinal motoneurones this current is predominantly mediated by influx of Caei through L-type Cae` channels of the Cav1.3 subtype. Depolarisation-induced facilitation of L-type Ca. channels is thought to be the mechanism for delayed activation (wind-up and warm-up) of the plateau potential and for the hysteresis in firing frequency and I-V relation during triangular depolarisation. L-type Cae’ channels and plateau potentials in spinal motoneurones are facilitated by activation of metabotropic receptors for glutamate, acetylcholine, noradrenaline and serotonin and down regulated by activation of GABAareceptors. The facilitation has been shown to depend on activated calmodulin.

Keywords

Motor Unit Rest Membrane Potential Dorsal Horn Neuron Metabotropic Receptor Plateau Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Aidas Alaburda
  • Jean-François Perrier
  • Jørn Hounsgaard
    • 1
  1. 1.MFI 12.5.9. The Panum InstituteCopenhagen UniversityDenmark

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