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Directions for Future Research

  • Lazaros C. Triarhou
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 517)

Abstract

Our groundwork, first, introduced and characterized in detail the weaver mouse as a model of spontaneous progressive dopamine (DA) deficiency similar to Parkinson’s disease, and secondly, laid the foundations for the intracerebral transplantation of catecholamine-producing neurons in this model of degeneration. Weaver mice represent the only known model of genetically-determined degeneration of the endogenous DA system and offer a unique opportunity to study the effects of a chronically ill environment on the fate of grafted DA neurons.

Keywords

Tyrosine Hydroxylase Nucleus Accumbens Basic Fibroblast Growth Factor Neural Transplantation Weaver Mutant Mouse 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Lazaros C. Triarhou
    • 1
  1. 1.University of MacedoniaThessalonikiGreece

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