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Behavioral Recovery of Functional Responses

  • Lazaros C. Triarhou
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 517)

Abstract

Studies in rats have shown that unilateral destruction of the nigrostriatal pathway by 6-hydroxydopamine (6-OHDA) results in a spontaneous rotational bias to the side ipsilateral to the lesion.’ With time, spontaneous rotational behavior subsides, but it can still be induced pharmacologically; amphetamine, an agent that releases dopamine (DA) from presynaptic terminals, causes a rotational bias to the side ipsilateral to the lesion;2apomorphine, a DA receptor agonist, causes rotation to the side contralateral to the lesion.3The effect of apomorphine is presumably a result of activating a greater number of DA receptors on the side of the lesion, due to the increase in receptors as a function of denervation supersensitivity.1, 2, 3, 4

Keywords

Substantia Nigra Rotational Behavior Nigrostriatal Dopamine Weaver Mouse Rotational Asymmetry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Lazaros C. Triarhou
    • 1
  1. 1.University of MacedoniaThessalonikiGreece

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