Neurochemical Indices of Functional Restoration

  • Lazaros C. Triarhou
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 517)


A general asset of the weaver model is that one can study graft development at the same time as the animal’s own dopamine (DA) system continues to undergo a progressive degeneration, which is reflected in the relatively slow loss of cells in the mutant, compared with the rapid and traumatic loss in neurotoxic lesion experiments. Adaptive changes to the striatal DA denervation also differ in many ways between the weaver mutant and the 6-hydroxydopamine (6-OHDA) model.1 In that respect, studies with lesion models2 and with genetic dissection through mutations3 may provide a complementary profile of graft effects and of graft-recipient interactions at structural and functional levels, pertinent to understanding cellular mechanisms of graft action both in the basic neuroscience and in the clinical setting, where 6-L-[18F]fluorodopa uptake is used to monitor the survival of human mesencephalic grafts in Parkinsonian patients.4,5


Nucleus Accumbens Neurotensin Receptor Muscimol Binding Weaver Mutant Mouse Spiperone Binding 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Lazaros C. Triarhou
    • 1
  1. 1.University of MacedoniaThessalonikiGreece

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