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Structural Correlates of Process Outgrowth and Circuit Reconstruction

  • Lazaros C. Triarhou
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 517)

Abstract

Certain cellular mechanisms by which grafts promote recovery in experimental animals have been deciphered.1, 2 It has been suggested that a multitude of trophic, neurohumoral and synaptic mechanisms could be involved in bringing about functional recovery in the nigrostriatal models.3

Keywords

Immunoreactive Nerve Junctional Contact Weaver Mutant Mouse Host Striatum Mesencephalic Graft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Isacson O, Deacon T. Neural transplantation studies reveal the brain’s capacity for continuous reconstruction. Trends Neurosci 1997; 20:477–482.PubMedGoogle Scholar
  2. 2.
    Olson L. Regeneration in the adult central nervous system: Experimental repair strategies. Nature Med 1997; 3:1329–1335.PubMedGoogle Scholar
  3. 3.
    Björklund A, Lindvall 0, Isacson O et al. Mechanisms of action of intracerebral neural implants: Studies on nigral and striatal grafts to the lesioned striatum. Trends Neurosci. 1098; 10:509–516.Google Scholar
  4. 4.
    Triarhou LC, Low WC, Ghetti B. Transplantation of ventral mesencephalic anlagen to hosts with genetic nigrostriatal dopamine deficiency. Proc Natl Acad Sei USA 1986; 83:8789–8793.Google Scholar
  5. 5.
    Triarhou LC, Low WC, Ghetti B. Synaptic investment of striatal cellular domains by grafted dopamine neurons in weaver mutant mice. Naturwissenschaften 1987; 74:591–593.PubMedGoogle Scholar
  6. 6.
    Triarhou LC, Low WC, Norton J et al. Reinstatement of synaptic connectivity in the striatum of weaver mutant mice following transplantation of ventral mesencephalic anlagen. J Neurocytol 1988; 17:233–243.PubMedGoogle Scholar
  7. 7.
    Triarhou LC, Low WC, Ghetti B. Genetic mesotelencephalic dopamine deficiency in weaver mutant mice: Reinstatement of neuronal connectivity by solid grafts of foetal mesencephalon. Fidia Res Series 1988; 15:183–192.Google Scholar
  8. 8.
    Triarhou LC, Low WC, Doucet G et al. The weaver mutant mouse as a model for intrastriatal grafting of fetal DA neurons. In: Hefti F, Weiner WJ, eds. Progress in Parkinson’s Disease Research-2. Mount Kisco, New York: Futura Publishing Co., 1992:389–400.Google Scholar
  9. 9.
    Björklund A, Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res 1979; 177:555–560.PubMedGoogle Scholar
  10. 10.
    Björklund A, Dunnett SB, Stenevi U et al. Reinnervation of the denervated striatum by substantia nigra transplants: Functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res 1980; 199:307–333.PubMedGoogle Scholar
  11. 11.
    Freund TF, Bolam JP, Björklund A et al. Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: A tyrosine hydroxylase immunocytochemical study. J Neurosci 1985; 5:603–616.PubMedGoogle Scholar
  12. 12.
    Mahalik Ti, Finger TE, Strömberg I et al. Substantia nigra transplants into denervated striatum of the rat: Ultrastructure of graft and host interconnections. J Comp Neurol 1985; 240:60–70.Google Scholar
  13. 13.
    Strömberg I, Johnson S, Hoffer B et al. Reinnervation of dopamine-denervated striatum by substantia nigra transplants: Immunohistochemical and electrophysiological correlates. Neuroscience 1985; 14:981–990.PubMedGoogle Scholar
  14. 14.
    Aguayo A, Björklund A, Stenevi U et al. Fetal mesencephalic neurons survive and extend long axons across peripheral nervous system grafts inserted into the adult striatum. Neurosci Lett 1984; 45:53–58.PubMedGoogle Scholar
  15. 15.
    Pickel VM, Beckley SC, Joh TH et al. Ultrastructural imtnunocytochemical localization of tyrosine hydroxylase in the neostriatum. Brain Res 1981; 225:373–385.PubMedGoogle Scholar
  16. 16.
    Freund TF, Powell TF, Smith AD. TH immunorcactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines. Neuroscience 1984; 13:1189–1215.PubMedGoogle Scholar
  17. 17.
    Purves D, Lichtman JW. Principles of Neural Development. Sunderland: Sinauer, 1985.Google Scholar
  18. 18.
    Beaudet A, Sotelo C. Synaptic remodelling of serotonin axon terminals in rat agranular cerebellum. Brain Res 1981; 206:305–329PubMedGoogle Scholar
  19. 19.
    Triarhou LC, Norton J, Ghetti B. Synaptic connectivity of tyrosine hydroxylase immunoreactive nerve terminals in the striatum of normal, heterozygous and homozygous weaver mutant mice. J Neurocytol 1988; 17:221–232.PubMedGoogle Scholar
  20. 20.
    Specht LA, Pickel VM, Joh TH et al. Fine structure of the nigrostriatal anlage in fetal rat brain by immunocytochemical localization of tyrosine hydroxylase. Brain Res 1981; 218:49–65.PubMedGoogle Scholar
  21. 21.
    Triarhou LC, Low WC, Ghetti B. Dopaminergic-cholinergic interactions following transplantation of ventral mesencephalic grafts to the weaver mouse neostriatum. Neurology 1991; 41[Suppl 1]:398.Google Scholar
  22. 22.
    Nestler EJ, Greengard P. Distribution of protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion. J Neurosci 1982; 2:1011–1023.PubMedGoogle Scholar
  23. 23.
    Mobley P, Greengard P. Evidence for widespread effects of noradrenaline on axon terminals in the rat frontal cortex. Proc Natl Acad Sci USA 1985; 82:945–947.PubMedGoogle Scholar
  24. 24.
    Low WC, Triarhou LC, Kaseda Y et al. Functional innervation of the striatum by ventral mesencephalic grafts in mice with inherited nigrostriatal dopamine deficiency. Brain Res 1987; 435:315–321.PubMedGoogle Scholar
  25. 25.
    Bolam JP, Freund TF, Björklund A et al, Synaptic input and local output of dopaminergic neurons in grafts that functionally reinnervate the host neostriatum. Exp Brain Res 1987; 68:131–146.PubMedGoogle Scholar
  26. 26.
    Triarhou LC, Brundin P, Doucet G et al. Intrastriatal implants of mesencephalic cell suspensions in weaver mutant mice: Ultrastructural relationships of dopaminergic dendrites and axons issued from the graft. Exp Brain Res 1990; 79:3–17.PubMedGoogle Scholar
  27. 27.
    Bohn MC, Cupit L, Marciano F et al, Adrenal medulla grafts enhance recovery of striatal dopaminergic fibers. Science 1987; 237:913–916.PubMedGoogle Scholar
  28. 28.
    Fuxe K, Hökfelt T, Nilsson O. Observations on the cellular localization of dopamine in the caudate nucleus of the rat. Z Zellforsch 1964; 63:701–706.PubMedGoogle Scholar
  29. 29.
    Doucet G, Descarr¨ªes L, Garcia S. Quantification of the dopamine innervation in adult rat neostriatum. Neuroscience 1986; 19:427–445.PubMedGoogle Scholar
  30. 30.
    Hökfelt T. In vitro studies on central and peripheral monoamine neurons at the ultrastructural level. Z Zellforsch 1968; 91:1–74.PubMedGoogle Scholar
  31. 31.
    Clarke DJ, Brundin P, Strecker RE et al. Human fetal dopamine neurons grafted in a rat model of Parkinson’s disease: Ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry, Exp Brain Res 1988; 73:115–126.PubMedGoogle Scholar
  32. 32.
    Triarhou LC, Low WC, Ghetti B. Dopamine neuron grafting to the weaver mouse neostriatum. Prog Brain Res 1990; 82:187–195.PubMedGoogle Scholar
  33. 33.
    Roffler-Tarlov S, Graybiel AM. The postnatal development of the dopamine-containing innervation of dorsal and ventral striatum: Effects of the weaver gene. J Neurosci 1987; 7:2364–2372.PubMedGoogle Scholar
  34. 34.
    Garcia-Segura LM, Baetens D, Roth J et al. Immunohistochemical mapping of calcium-binding protein immunoreactivity in the rat central nervous system, Brain Res 1984; 296:75–86.PubMedGoogle Scholar
  35. 35.
    Enderlin S, Norman AW, Cello MR. Ontogeny of the calcium binding protein calbindin D-28k in the rat nervous system. Anat Embryol (Berl) 1987; 177:15–28.Google Scholar
  36. 36.
    Schultzberg M, Dunnett SB, Björklund A et al. Dopamine and cholecystokin¨ªn immunoreactive neurons in mesencephalic grafts reinnervating the neostriatum: Evidence for selective growth regulation. Neuroscience 1984; 12:17–32.PubMedGoogle Scholar
  37. 37.
    Fallon JR. Collateralization of monoamine neurons: Mesotelencephalic dopamine projections to caudate, septum, and frontal cortex. J Neurosci 1981; 1:1361–1368.PubMedGoogle Scholar
  38. 38.
    Lindvall O. Mesencephalic dopaminergic afferents to the lateral septal nucleus of the rat. Brain Res 1975; 87:89–95.PubMedGoogle Scholar
  39. 39.
    Thierry AM, Blanc G, Sobel A et al. Dopaminergic terminals in the rat cortex. Science 1973; 182:499–501.PubMedGoogle Scholar
  40. 40.
    Fuxe K, Hökfelt T, Johansson O et al. The origin of the dopamine nerve terminals in limbic and frontal cortex. Evidence for meso-cortico dopamine neurons. Brain Res 1974: 82:349–355.Google Scholar
  41. 41.
    Lindvall O, Björklund A, Moore RY et al. Mesencephalic dopamine neurons projecting to neocortex. Brain Res 1974; 81:325–331.PubMedGoogle Scholar
  42. 42.
    Lindvall O, Björklund A, Divac I. Organization of catecholamine neurons projecting to the frontal cortex in rat. Brain Res 1978; 142:1–24.PubMedGoogle Scholar
  43. 43.
    Emson PC, Koob GF. The origin and distribution of dopamine-containing afferents to the rat frontal cortex. Brain Res 1978; 142:249–267.PubMedGoogle Scholar
  44. 44.
    Björklund A, Lindvall O. Dopamine-containing systems in the CNS. In: Björklund A, Hökfelt T (eds). Handbook of Chemical Neuroanatomy, vol 2. Amsterdam-New York-Oxford: Elsevier, 1984:55–122.Google Scholar
  45. 45.
    Van Eden CG, Hoomeman EMD, Buijs RM et al. Immunocytochemical localization of dopamine in the prefrontal cortex of the rat at the light and electron microscopic level. Neuroscience 1987; 22:849–862.PubMedGoogle Scholar
  46. 46.
    Routtenberg A. The reward system of the brain. Sci Am 1978; 239:154–164.PubMedGoogle Scholar
  47. 47.
    Scamati E, Forchetti C, Ruggieri S et al. Dopamine and dementia. An animal model with destruction of the mesocortical dopaminergic pathway: A preliminary study. In: Amaducci L, Davison AN, Antuono P, eds. Aging of the Brain and Dementia. New York: Raven Press, 1980:139–145.Google Scholar
  48. 48.
    Fink JS, Smith GP. Mesolimbic and mesocortical dopaminergic neurons are necessary for normal exploratory behavior in rats. Neurosci Lett 1980; 17:61–65.PubMedGoogle Scholar
  49. 49.
    Thierry AM, Tassin JP, Blanc G et al. Selective activation of the mesocortical DA system by stress. Nature (Lond) 1976; 263:242–244.Google Scholar
  50. 50.
    Scatton B, Rouquier L, Javoy-Agid F et al. Dopamine deficiency in the cerebral cortex in Parkinson disease. Neurology 1982; 32:1039–1040.PubMedGoogle Scholar
  51. 51.
    Candy JM, Perry RH, Perry EK et al. Pathological changes in the nucleus of Meynert in Alzheimer’s and Parkinson’s diseases. J Neurol Sci 1983; 59:277–289.PubMedGoogle Scholar
  52. 52.
    Whitehouse PJ, Hedreen JC, White CL III et al. Basal forebrain neurons in the dementia of Parkinson disease. Ann Neurol 1983; 13:243–248.PubMedGoogle Scholar
  53. 53.
    Brozoski TJ, Brown RM, Rosvold HE et al. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 1979; 205:929–932.PubMedGoogle Scholar
  54. 54.
    Schmidt MI, Sawyer BD, Perry KW et al. Dopamine deficiency in the weaver mutant mouse. J Neurosci 1982; 2:376–380.PubMedGoogle Scholar
  55. 55.
    Triarhou LC, Norton J, Ghetti B (1988) Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mutant mice. Exp Brain Res 1988; 70:256–265.PubMedGoogle Scholar
  56. 56.
    Triarhou LC, Low WC, Ghetti B. Layer-specific innervation of the dopamine-deficient frontal cortex in weaver mutant mice by grafted mesencephalic dopaminergic neurons. Cell Tissue Res 1988; 254:11–15.PubMedGoogle Scholar
  57. 57.
    Langley JN. Note on regeneration of preganglionic fibres of the sympathetic. J Physiol 1895; 18:280–284.PubMedGoogle Scholar
  58. 58.
    Cajal SR (1929) Studies on Vertebrate Neurogenesis (Guth L, transi). Springfield: Charles C Thomas, 1960.Google Scholar
  59. 59.
    Sperry RW. Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc Natl Acad Sci USA 1963; 50:703–710.PubMedGoogle Scholar
  60. 60.
    Sperry RW, Arora HL. Selectivity in regeneration of the oculomotor nerve in the cichlid fish, Astronatus ocellatus. J Embryol Exp Morphol 1965; 14:307–317.PubMedGoogle Scholar
  61. 61.
    Hob JFY. Selective and nonselective reinnervation of fast-twitch and slow-twitch rat skeletal muscle. J Physiol 1975; 251:791–801.Google Scholar
  62. 62.
    Van Essen DC, Jansen JKS. The specificity of reinnervation by identified sensory and motor neurons in the leech. J Comp Neurol 1977; 171:433–454.PubMedGoogle Scholar
  63. 63.
    Purves D, Thompson W, Yip JW. Re-innervation of ganglia transplanted to the neck from different levels of the guinea-pig sympathetic chain. J Physiol 1981; 313:49–63.PubMedGoogle Scholar
  64. 64.
    Landmesser L, Pilar G. Selective reinnervation of two cell populations in the adult pigeon ciliary ganglion. J Physiol 1970; 211:203–216.PubMedGoogle Scholar
  65. 65.
    Sperry RW (1943) Effect of 180 degree rotation of the retinal field on visuomotor coordination. J Exp Zool 1943; 92:263–279.Google Scholar
  66. 66.
    Stone LS. Functional polarization in the retinal development and its reestablishment in regenerating retinae of rotated grafted eyes. Proc Soc Exp Biol Med 1944; 57:13–14.Google Scholar
  67. 67.
    Attardi DG, Sperry RW. Preferential selection of central pathways by regenerating optic fibers. Exp Neurol 1963; 7:46–64PubMedGoogle Scholar
  68. 68.
    Björklund A, Stenevi U, Schmidt RH et al. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiol Scand 1983; [Suppl] 522:9–18.Google Scholar
  69. 69.
    Herman JP, Choulli K, Geffard M et al. Reinnervation of the nucleus accumbens and frontal cortex of the rat by dopaminergic grafts and effects on hoarding behavior. Brain Res 1986; 372:210–216.PubMedGoogle Scholar
  70. 70.
    Björklund A, Stenevi U, Svendgaard N-A. Growth of transplanted monoaminergic neurones into the adult hippocampus along the perforant path. Nature (Lund) 1976; 262:787–790.Google Scholar
  71. 71.
    Björklund A, Stenevi U. Reformation of the severed septohippocampal cholinergie pathway in the adult rat by transplanted septal neurons. Cell Tissue Res 1977; 185:289–302.PubMedGoogle Scholar
  72. 72.
    Dunnett SB, Low WC, Iversen SD et al. Septal transplants restore maze learning in rats with fornix-fimbria lesions. Brain Res 1982; 251:335–348.PubMedGoogle Scholar
  73. 73.
    Sharkey MA, Steedman JG, Lund RD et al. Tectal transplants into the occipital cortex of the newborn rat. Dev Brain Res 1987; 31:119–123.Google Scholar
  74. 74.
    Björklund A, Lindvall O. Dopamine in dendrites of substantia nigra neurons: Suggestions for a role in dendritic terminals. Brain Res 1975; 83:531–537.PubMedGoogle Scholar
  75. 75.
    Ch¨¦ramy A, Leviel V, Glowinski J. Dendritic release of dopamine in the substantia nigra. Nature (Lund) 1981; 289:537–542.Google Scholar
  76. 76.
    Korf J, Zieleman M, Westerink BHC. Dopamine release in substantia nigra7 Nature (Lond) 1976; 260:257–258.Google Scholar
  77. 77.
    Geffen LB, Jessell TM, Cuello AC et al. Release of dopamine from dendrites in rat substantia nigra. Nature 1976; 260:258–260.PubMedGoogle Scholar
  78. 78.
    Wassef M, Berod A, Sotelo C. Dopaminergic dendrites in the pars reticulata of the rat substantia nigra and their striatal input: Combined immunocytochemical localization of tyrosine hydroxylase and anterograde degeneration. Neuroscience 1981; 6:2125–2139.PubMedGoogle Scholar
  79. 79.
    Triarhou LC, Sol¨¤ C, Mengod G et al. Ventral mesencephalic grafts in the neostriatum of the weaver mutant mouse: Structural molecule and receptor studies. Cell Transpl 1995; 4:39–48.Google Scholar
  80. 80.
    Sol¨¤ C, Mengod G, Low WC et al. Regional distribution of amyloid ß-protein precursor, growth-associated phosphoprotein-43 and microtubule-associated protein 2 mRNAs in the nigrostriatal system of normal and weaver mutant mice and effects of ventral mesencephalic grafts. Eur J Neurosci 1993; 5:1442–1454.Google Scholar
  81. 81.
    Edelman GM, Crossin KL. Cell adhesion molecules: Implications for a molecular histology. Ann Rev Biochem 1991; 60:155–190.PubMedGoogle Scholar
  82. 82.
    Sanes JR. Extracellular matrix molecules that influence neural development. Ann Rev Neurosci 1989; 12:491–516.PubMedGoogle Scholar
  83. 83.
    Bendotti C, Servadio A, Samanin R. Distribution of GAP-43 mRNA in the brain stem of adult rats as evidenced by in situ hybridization: Localization within monoaminergic neurons. J Neurosci 1991; 11:600–607PubMedGoogle Scholar
  84. 84.
    BenowitzLI,Apostolides PJ, Perrone-Bizzozero N et al. Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain. J Neurosci 1988; 8:339–352.PubMedGoogle Scholar
  85. 85.
    Meiri K, Bickerstaff LE, Schwob JE. Monoclonal antibodies show that kinase C phosphorylation of GAP-43 during axonogenesis is both spatially and temporally restricted in vivo. J Cell Riot 1991; 112:991–1005.Google Scholar
  86. 86.
    Meiri KF, Pfenninger KH, Willard MB. Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones. Proc Natl Acad Sci USA 1986; 83:3537–3541.PubMedGoogle Scholar
  87. 87.
    Palacios G, Mengod G, Sarasa M et al. De novo synthesis of GAP-43: In situ hybridization histochemistry and light and electron microscopy immunocytochemical studies in regenerating motor neurons of cranial nerve nuclei in the rat brain. Mol Brain Res 1994; 24:107–117.PubMedGoogle Scholar
  88. 88.
    Poltorak M, Freed WJ, Sternberger LA et al. A comparison of intraventricular and intraparenchymal cerebellar allografts in rat brain: evidence for normal phosphorylation of neurafrlaments. J Neuroimmunol 1988; 20:63–72.PubMedGoogle Scholar
  89. 89.
    Sternberger LA, Sternberger NH. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci USA 1983; 80:6126–6130.PubMedGoogle Scholar
  90. 90.
    Jahn R, Schiebler W, Ouimet C et al. A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 1985; 82:4137–4141.PubMedGoogle Scholar
  91. 91.
    Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein of M. 38,000 characteristic of presynaptic vesicles. Cell 1985; 41:1017–1028.PubMedGoogle Scholar
  92. 92.
    Goslin K, Schreyer DJ, Skene JH et al. Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones. Nature (Lond) 1988; 336:672–674.Google Scholar
  93. 93.
    Kosik KS, Orecchio LD, Bruns GA et al. Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. Neuron 1988; 1:127–132.PubMedGoogle Scholar
  94. 94.
    Matus A. Microtubule-associated proteins: their potential role in determining neuronal morphology. Ann Rev Neurosci 1988; 11:29–44.PubMedGoogle Scholar
  95. 95.
    De la Monte SM, Federoff HJ, Ng S et al. GAP-43 gene expression during development: Persistence in a distinctive set of neurons in the mature central nervous system. Dev Brain Res 1989; 46:161–168.Google Scholar
  96. 96.
    Meberg PJ, Routtenberg A. Selective expression of protein Fl/(GAP-43) mRNA in pyramidal but not granule cells of the hippocampus. Neuroscience 1991; 45:721–733.PubMedGoogle Scholar
  97. 97.
    DiFiglia M, Roberts RC, Benowitz LI. Immunoreactive GAP-43 in the neuropil of adult rat neostriatum: Localization in unmyelinated fibers, axon terminals and dendritic spines. J Comp Neurol 1990; 302:992–1001.PubMedGoogle Scholar
  98. 98.
    Campbell G, Anderson PN, Turmaine M et al. GAP-43 in the axons of mammalian CNS neurons regenerating into peripheral nerve grafts. Exp Brain Res 1991; 87:67–74.PubMedGoogle Scholar
  99. 99.
    Clayton GH, Mahalik TJ, Finger TE. GAP-43 and 5B4-CAM immunoreactivity during the development of transplanted fetal mesencephalic neurons. Exp Neurol 1991; 114:1–10.PubMedGoogle Scholar
  100. 100.
    Clayton GH, Mahalik TJ. GAP-43 expression in neurochemically identified subpopulations of neurons within fetal ventral mesencephalic transplants. Restor Neurol Neurosci 1992; 4:160.Google Scholar
  101. 101.
    Halpain S, Greengard P. Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2. Neuron 1990; 5:237–246.PubMedGoogle Scholar
  102. 102.
    Yamada T, Akiyama H, McGeer PL. Two types of spheroid bodies in the nigral neurons in Parkinson’s disease. Can J Neurol Sci 1991; 18:287–294.PubMedGoogle Scholar
  103. 103.
    Triarhou LC, Ghetti B. Further characterization of the dopaminergic dendrite deficit in substantia nigra pars reticulata of heterozygous and homozygous weaver mutant mice: Golgi, MAP2 and synaptic connectivity studies. Soc Neurosci Abstr 1991; 17:159.Google Scholar
  104. 104.
    Triarhou LC. Weaver gene expression in central nervous system. In: Conn PM, ed. Methods in Neurosciences, vol 9: Gene Expression in Neural Tissues. San Diego: Academic Press, 1992:209–227Google Scholar
  105. 105.
    Doering LC. Transplantation of fetal CNS tissue into the peripheral nervous system: A model to study aberrant changes in the neuronal cytoskeleton. J Neural Transpl Plast 1991; 2:193–205.Google Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Lazaros C. Triarhou
    • 1
  1. 1.University of MacedoniaThessalonikiGreece

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