Biology and Pathology of the Weaver Mutant Mouse

  • Lazaros C. Triarhou
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 517)


The weaver mutant mouse(wv/wv)is characterized by a genetically-induced degeneration of mesostriatal dopamine (DA) neurons. In that sense, it can be viewed as a pathophysiological phenocopy of Parkinsonism and, therefore, an invaluable experimental model for investigating mechanisms of progressive DA neuron degeneration, as well as issues of the survival and growth of intrastriatally grafted fetal DA neurons in the chronically denervated striatum.1, 2, 3


Purkinje Cell Granule Cell Substantia Nigra Ventral Tegmental Area Purkinje Cell Loss 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Lazaros C. Triarhou
    • 1
  1. 1.University of MacedoniaThessalonikiGreece

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