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Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 517))

Abstract

Movement control is accomplished by complex interactions among various groups of nerve cells in the central nervous system. One such important group of neurons is located in the substantia nigra in the ventral midbrain. Nigral neurons give rise to an extensive network of axonal processes that innervate the basal ganglia, establishing predominantly symmetrical synapses with dendritic spines and shafts of medium spiny projection neurons. 1,2 Neurons of the substantia nigra communicate with neurons of the basal ganglia by liberating the neurotransmitter dopamine (DA). Such an interaction at the biochemical level is responsible for the fine tuning of an organism’s movements.

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  1. University of Macedonia, Thessaloniki, Greece

    Lazaros C. Triarhou

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Triarhou, L.C. (2002). Introduction. In: Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease. Advances in Experimental Medicine and Biology, vol 517. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0699-7_1

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