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Tyrosine phosphorylation of PICOT and its translocation to the nucleus in response of human T cells to oxidative stress

  • Yael Babichev
  • Noah Isakov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

Protein kinase C θ (PKCθ) is a Ca2+-independent isoform expressed in T but not B lymphocytes, and is therefore suggested as being linked to the T cell antigen receptor (TCR) function (1 2). PKCθ was shown to function as an upstream regulator of critical transcription factors, such as AP-1 and NF-KB, in activated T lymphocytes (3). More recent studies demonstrated that PKCθ colocalizes with the TCR at the core of the supramolecular activation complex (SMAC) formed at the contact region between antigen-responding T cells and antigen-presenting cells (APC) (4). Finally, PKCθ—deficient mice were found to be impaired in T cell-mediated immune responses, apparently, due to inability of their antigen triggered T cells to activate the AP-1 and NF-κB transcription factors (5).

Keywords

Tyrosine Phosphorylation Reactive Oxygen Intermediate Induce Tyrosine Phosphorylation Critical Transcription Factor Cell Activation Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Yael Babichev
    • 1
  • Noah Isakov
    • 1
  1. 1.Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research CenterBen-Gurion UniversityBeer ShevaIsrael

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