Abstract
The antitumor effects of cytokines used in cancer immunotherapy depend on the actual balance between the host immune system and a growing tumor. One of the most potent regulatory molecules that play a critical role in generating a successful immune response is interleukin-2 (IL-2), which like other cytokines, acts in a paracrine and autocrine manner. The cytokine induces a broad spectrum of biological events, which in some cases lead to tumor regression. Among others IL-2 stimulates the proliferation of CD8+T cells and their IFN-y production. By initiation of cascade of secondary cytokines, especially IFN and TNF-a, IL-2 is also involved in activation of macrophages. Activated macrophages produce nitric oxide (NO), defined as an effector molecule that can kill or inactivate target cells.
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Pajtasz-Piasecka, E., Kuśnierczyk, H., Krawczyk, K.P., Piasecki, E., Elas, M., Radzikowski, C. (2001). The effects of peritumoral therapeutic vaccination with IL-2-secreting cells on growth of MC38 colon tumours in mice, local NO production and sentinel lymph node cells activation. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_56
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DOI: https://doi.org/10.1007/978-1-4615-0685-0_56
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5194-8
Online ISBN: 978-1-4615-0685-0
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