Abstract
In the T-cell lineage, several pathways have been identified which regulate apoptosis. In particular, in normal T lymphocytes activation, differentiation and death are under regulation of a number of signals and stimuli that can contribute either to positive or negative selection1-5.
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Jenkinson, E.J., Kingston, R., Smith, C.A., Williams, G.T., and Owen, J.J., 1989, Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire.Eur. J. Immunol.19:2175–2177.
MacDonald, H.R., and Lees., R.K., 1990, Programmed death of autoreactive thymocytes.Nature343:642–644.
Raff, M.C., 1992, Social controls on cell survival and cell death.Nature356:397399.
Boise, L.H., and Thompson, C.G., 1996, Hierarchical control of lymphocyte survival.Science274:67–68.
Backstrom, B.T., Muller, U., Hausmann, B., and Palmer, E., 1998, Positive selection through a motif in the aß T cell receptor.Science281:835–838.
Webb, S., Morris, C., Sprent, J., 1990, Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity.Cell63:1249–1254.
Kabelitz, D., Pohl, T., and Pechhold, K., 1993, Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes.Immunol. Today14:338–339.
Ju, S.T., Panka, D.J., Cui, H., Ettiger, R., el-Khatib, M., Sherr, D.H., Stanger, B.Z., and Marshak-rothstein, A., 1995, Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.Nature373:444–448.
Suda, T., Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S., Nakao, K., and Nagata, S., 1995, Expression of the Fas ligand in cells of T cell lineage.J. Immunol.154:3806–3813.
Green, D.R., and Ware, C.F., 1997, Fas-ligand: privilege and peril.Proc. Natl. Acad Sci. USA94:5986–5990.
Jain, J., Loh, C., and Rao, A, 1995, Transcriptional regulation of the IL-2 gene.Curr. Opin. Immunol.7:333–342.
Boothby, M.R., Mora, A.L., Scherer, D.C., Brockman, J.A., and Ballard, D.W., 1997, Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.J. Exp. Med.185:1897–1907.
Kuo, C.T., Veselits, M.L., and Leiden, J.M., 1997, LKLF: a transcriptional regulator of single-positive T cell quiescence and survival.Science277:1886–1990.
Magginvar, S.B., Harhaj, E.W., and Sun, S.C., 1997, Regulation of the interleukin-2 CD28 responsive element by NF-Atp and various NF-kappaB/Rel transcription factors.Mol. Cell. Biol.17:2605–2614.
Gerondakis, S., Grumont, R., Ropurke, R., and Grossman, M., 1998, The regulation and roles of Rel/NF-kappaB transcription factors during lymphocyte activation.Curr. Opin. Immunol.10:353–359.
Lin, B., William-Skipp, C., Tao, Y., Schleicher, M.S., Cano, L.L., Duke, R.C., and Scheinman, R.I., 1999, NF-kB functions as both proapoptotic and antiapoptotic regulatory factor within a single cell type.Cell Death Differ6:570–582.
Migliorati, G., Nicoletti, I., Pagliacci M.C., D’Adamio, L., and Riccardi, C., 1993, Interleukin-4 Protects Double-Negative and CD4 Single-Positive Thymocytes from Dexamethasone-Induced ApoptosisBlood81:1352–1358.
Ayroldi, E., Zollo O., Cannarile, L., D’Adamio F., Grohmann, U., Delfino, V.D., and Riccardi, C., 1998, Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2-Independent Inhibition of Fas/fasL Expression and Cell DeathBlood92:42124219.
Ayroldi, E., Migliorati G., Cannarile, L., Moraca, R., Delfino, D., and Riccardi, C., 1997, CD2 rescues T cells from T-cell receptor/CD3 apoptosis: a role for the Fas/FasL systemBlood89 3717–37.
Wyllie, A.H., 1972, Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.Nature284:555–558.
Cohen, J.J., and Duke, R.C., 1984, Glucocorticoid activation of a calcium dependent endonuclease in thymocyte nuclei leads to cell death.J. Immunol.132:38–43.
Vacchio, M.S., Papadopoulos, V., and Ashwell, J.D., 1994, Steroid production in the thymus: implications for thymocyte selection.J. Exp. Med.179:1835–1846.
Chrousos, G.P., 1995, The hypothalamic-pituitary-adrenal axis and immune mediated inflammation.N. Engl. J. Med.332:1351–1362.
King, L.B., Vacchio, M.S., Dixon, K., Hunziker, R., Margulies, D.H., and Ashwell, J.D., 1995, A targeted Glucocorticoid receptor antisense transgene increases thymocyte development.Immunity3:647–656.
Riccardi, C., Cifone, G., and Migliorati, G., 1999, Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes.Cell Death Differ.12:1155–1163.
Yang, Y., Mercep, M., Ware C.F., and Ashwell, J.D., 1995, Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.J. Exp. Med.181:1673–1682.
Ramdas, J., and Harmon, J.M., 1998, Glucocorticoid-Induced Apoptosis and Regulation of NF-1(B Activity in Human Leukemic T Cells.Endocrinology139:3813–3821.
Ray, A., and Prefontaine, K.E., 1994, Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappaB and the glucocorticoid receptor.Proc. Natl. Acad. Sci. USA91:752–756.
Auphan, N., DiDonato, J.A., Rosette, C., Hejmberg, A., and Karin, M., 1995, Immunosuppression by glucocorticoids: inhibition by NF-kB activity through induction of IkB synthesis.Science270:286–290.
Caldenhoven, E., Liden, J., Wissink, S., Van de Stolpe, A., Raaijmakers, J., Koenderman, L., Okret, S., Gustafsson, J.A., and Van der Saag, P.T., 1995, Negative cross-talk between ReIA and the glucocorticoid receptor: a possible mechanism for the antinflammatory action of glucocorticoids.Molecular Endocrinology9:401–412.
Scheinman, RI., Cogswell, P.C., Lofquist, A.K., and Baldwin Jr., A.S., 1995 Role of transcriptional activation of IkBa in mediation of immunosuppression by glucocorticoids.Science270:283–286.
Scheinman, RI., Gualberto, A., Jewell, C.M., Cidlowski, J.A., and Baldwin Jr, A.S., 1995, Characterization of the Mechanisms Involved in the Transrepression of NF-kB by Activated Glucocorticoid Receptors.Mol. Cell. Biol.15:943–953.
De Bosscher, K., Schimtz, M.L., Vanden Berghe, W., Plaisance, S., Fiers, W., and Haegeman, G., 1997, Glucocorticoid-mediated repression of nuclear factor-kappaBdependent transcription involves direct interference with transactivation.Proc. Natl. Acad. Sci. USA94:13504–13509.
Nocentini, G., Giunchi, L., Ronchetti, S., Krausz, L.T., Bartoli, A., Moraca, R, Migliorati, G., and Riccardi, C., 1997, A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis.Proc. Nad. Acad. Sci. USA94: 6216–6221.
Nocentini, G., Bartoli, A., Ronchetti, S., Giunchi, L., Cupelli, A., Delfino, D., Migliorati, G., and Riccardi, C., 2000 Gene Structure and Chromosomal Assignment of Mouse GITR, a Member of Tumor Necrosis Factor/Nerve Growth Factor Receptor FamilyDNA and Cell Biology19:205–217.
Nocentini, G., Ronchetti, S., Bartoli, A., Spinicelli, S., Delfino, D., Brunetti, L., Migliorati, G., and Riccardi, C., 2000, Identification of three novel mRNA splice variants of GITRCell Death and D fferentation7:408–410.
D’Adamio, F., Zollo, O., Moraca, R., Ayroldi, E., Bruscoli, S., Bartoli, A., Cannarile, L., Migliorati, G., and Riccardi, C., 1997, A new Dexamethasone-induced gene of the leucin e zipper family protects T lymphocytes from TCR/CD3-activated cell death.Immunity7:803–812.
Cannarile, L., Zollo, O., D’Adamio, F., Ayroldi, E., Marchetti, C., Tabilio, A., bruscoli, S., and Riccardi, C., 2001, Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced geneCell Death and DifferentationPlenum Press.
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Riccardi, C., Bruscoli, S., Ayroldi, E., Agostini, M., Migliorati, G. (2001). GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kB. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_5
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DOI: https://doi.org/10.1007/978-1-4615-0685-0_5
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