Skip to main content

GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kB

  • Chapter
Progress in Basic and Clinical Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 495))

Abstract

In the T-cell lineage, several pathways have been identified which regulate apoptosis. In particular, in normal T lymphocytes activation, differentiation and death are under regulation of a number of signals and stimuli that can contribute either to positive or negative selection1-5.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jenkinson, E.J., Kingston, R., Smith, C.A., Williams, G.T., and Owen, J.J., 1989, Antigen-induced apoptosis in developing T cells: a mechanism for negative selection of the T cell receptor repertoire.Eur. J. Immunol.19:2175–2177.

    Article  PubMed  CAS  Google Scholar 

  2. MacDonald, H.R., and Lees., R.K., 1990, Programmed death of autoreactive thymocytes.Nature343:642–644.

    Article  PubMed  CAS  Google Scholar 

  3. Raff, M.C., 1992, Social controls on cell survival and cell death.Nature356:397399.

    Google Scholar 

  4. Boise, L.H., and Thompson, C.G., 1996, Hierarchical control of lymphocyte survival.Science274:67–68.

    Article  PubMed  CAS  Google Scholar 

  5. Backstrom, B.T., Muller, U., Hausmann, B., and Palmer, E., 1998, Positive selection through a motif in the aß T cell receptor.Science281:835–838.

    Article  PubMed  CAS  Google Scholar 

  6. Webb, S., Morris, C., Sprent, J., 1990, Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity.Cell63:1249–1254.

    Article  PubMed  CAS  Google Scholar 

  7. Kabelitz, D., Pohl, T., and Pechhold, K., 1993, Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes.Immunol. Today14:338–339.

    Article  PubMed  CAS  Google Scholar 

  8. Ju, S.T., Panka, D.J., Cui, H., Ettiger, R., el-Khatib, M., Sherr, D.H., Stanger, B.Z., and Marshak-rothstein, A., 1995, Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.Nature373:444–448.

    Article  PubMed  CAS  Google Scholar 

  9. Suda, T., Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S., Nakao, K., and Nagata, S., 1995, Expression of the Fas ligand in cells of T cell lineage.J. Immunol.154:3806–3813.

    PubMed  CAS  Google Scholar 

  10. Green, D.R., and Ware, C.F., 1997, Fas-ligand: privilege and peril.Proc. Natl. Acad Sci. USA94:5986–5990.

    Article  PubMed  CAS  Google Scholar 

  11. Jain, J., Loh, C., and Rao, A, 1995, Transcriptional regulation of the IL-2 gene.Curr. Opin. Immunol.7:333–342.

    Article  PubMed  CAS  Google Scholar 

  12. Boothby, M.R., Mora, A.L., Scherer, D.C., Brockman, J.A., and Ballard, D.W., 1997, Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.J. Exp. Med.185:1897–1907.

    Article  PubMed  CAS  Google Scholar 

  13. Kuo, C.T., Veselits, M.L., and Leiden, J.M., 1997, LKLF: a transcriptional regulator of single-positive T cell quiescence and survival.Science277:1886–1990.

    Article  Google Scholar 

  14. Magginvar, S.B., Harhaj, E.W., and Sun, S.C., 1997, Regulation of the interleukin-2 CD28 responsive element by NF-Atp and various NF-kappaB/Rel transcription factors.Mol. Cell. Biol.17:2605–2614.

    Google Scholar 

  15. Gerondakis, S., Grumont, R., Ropurke, R., and Grossman, M., 1998, The regulation and roles of Rel/NF-kappaB transcription factors during lymphocyte activation.Curr. Opin. Immunol.10:353–359.

    Article  PubMed  CAS  Google Scholar 

  16. Lin, B., William-Skipp, C., Tao, Y., Schleicher, M.S., Cano, L.L., Duke, R.C., and Scheinman, R.I., 1999, NF-kB functions as both proapoptotic and antiapoptotic regulatory factor within a single cell type.Cell Death Differ6:570–582.

    Article  PubMed  CAS  Google Scholar 

  17. Migliorati, G., Nicoletti, I., Pagliacci M.C., D’Adamio, L., and Riccardi, C., 1993, Interleukin-4 Protects Double-Negative and CD4 Single-Positive Thymocytes from Dexamethasone-Induced ApoptosisBlood81:1352–1358.

    PubMed  CAS  Google Scholar 

  18. Ayroldi, E., Zollo O., Cannarile, L., D’Adamio F., Grohmann, U., Delfino, V.D., and Riccardi, C., 1998, Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2-Independent Inhibition of Fas/fasL Expression and Cell DeathBlood92:42124219.

    Google Scholar 

  19. Ayroldi, E., Migliorati G., Cannarile, L., Moraca, R., Delfino, D., and Riccardi, C., 1997, CD2 rescues T cells from T-cell receptor/CD3 apoptosis: a role for the Fas/FasL systemBlood89 3717–37.

    PubMed  CAS  Google Scholar 

  20. Wyllie, A.H., 1972, Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.Nature284:555–558.

    Article  Google Scholar 

  21. Cohen, J.J., and Duke, R.C., 1984, Glucocorticoid activation of a calcium dependent endonuclease in thymocyte nuclei leads to cell death.J. Immunol.132:38–43.

    PubMed  CAS  Google Scholar 

  22. Vacchio, M.S., Papadopoulos, V., and Ashwell, J.D., 1994, Steroid production in the thymus: implications for thymocyte selection.J. Exp. Med.179:1835–1846.

    Article  PubMed  CAS  Google Scholar 

  23. Chrousos, G.P., 1995, The hypothalamic-pituitary-adrenal axis and immune mediated inflammation.N. Engl. J. Med.332:1351–1362.

    Article  PubMed  CAS  Google Scholar 

  24. King, L.B., Vacchio, M.S., Dixon, K., Hunziker, R., Margulies, D.H., and Ashwell, J.D., 1995, A targeted Glucocorticoid receptor antisense transgene increases thymocyte development.Immunity3:647–656.

    Article  PubMed  CAS  Google Scholar 

  25. Riccardi, C., Cifone, G., and Migliorati, G., 1999, Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes.Cell Death Differ.12:1155–1163.

    Google Scholar 

  26. Yang, Y., Mercep, M., Ware C.F., and Ashwell, J.D., 1995, Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.J. Exp. Med.181:1673–1682.

    Article  PubMed  CAS  Google Scholar 

  27. Ramdas, J., and Harmon, J.M., 1998, Glucocorticoid-Induced Apoptosis and Regulation of NF-1(B Activity in Human Leukemic T Cells.Endocrinology139:3813–3821.

    Article  PubMed  CAS  Google Scholar 

  28. Ray, A., and Prefontaine, K.E., 1994, Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappaB and the glucocorticoid receptor.Proc. Natl. Acad. Sci. USA91:752–756.

    Article  PubMed  CAS  Google Scholar 

  29. Auphan, N., DiDonato, J.A., Rosette, C., Hejmberg, A., and Karin, M., 1995, Immunosuppression by glucocorticoids: inhibition by NF-kB activity through induction of IkB synthesis.Science270:286–290.

    Article  PubMed  CAS  Google Scholar 

  30. Caldenhoven, E., Liden, J., Wissink, S., Van de Stolpe, A., Raaijmakers, J., Koenderman, L., Okret, S., Gustafsson, J.A., and Van der Saag, P.T., 1995, Negative cross-talk between ReIA and the glucocorticoid receptor: a possible mechanism for the antinflammatory action of glucocorticoids.Molecular Endocrinology9:401–412.

    Article  PubMed  CAS  Google Scholar 

  31. Scheinman, RI., Cogswell, P.C., Lofquist, A.K., and Baldwin Jr., A.S., 1995 Role of transcriptional activation of IkBa in mediation of immunosuppression by glucocorticoids.Science270:283–286.

    Article  PubMed  CAS  Google Scholar 

  32. Scheinman, RI., Gualberto, A., Jewell, C.M., Cidlowski, J.A., and Baldwin Jr, A.S., 1995, Characterization of the Mechanisms Involved in the Transrepression of NF-kB by Activated Glucocorticoid Receptors.Mol. Cell. Biol.15:943–953.

    PubMed  CAS  Google Scholar 

  33. De Bosscher, K., Schimtz, M.L., Vanden Berghe, W., Plaisance, S., Fiers, W., and Haegeman, G., 1997, Glucocorticoid-mediated repression of nuclear factor-kappaBdependent transcription involves direct interference with transactivation.Proc. Natl. Acad. Sci. USA94:13504–13509.

    Article  PubMed  CAS  Google Scholar 

  34. Nocentini, G., Giunchi, L., Ronchetti, S., Krausz, L.T., Bartoli, A., Moraca, R, Migliorati, G., and Riccardi, C., 1997, A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis.Proc. Nad. Acad. Sci. USA94: 6216–6221.

    Article  CAS  Google Scholar 

  35. Nocentini, G., Bartoli, A., Ronchetti, S., Giunchi, L., Cupelli, A., Delfino, D., Migliorati, G., and Riccardi, C., 2000 Gene Structure and Chromosomal Assignment of Mouse GITR, a Member of Tumor Necrosis Factor/Nerve Growth Factor Receptor FamilyDNA and Cell Biology19:205–217.

    Article  PubMed  CAS  Google Scholar 

  36. Nocentini, G., Ronchetti, S., Bartoli, A., Spinicelli, S., Delfino, D., Brunetti, L., Migliorati, G., and Riccardi, C., 2000, Identification of three novel mRNA splice variants of GITRCell Death and D fferentation7:408–410.

    Article  CAS  Google Scholar 

  37. D’Adamio, F., Zollo, O., Moraca, R., Ayroldi, E., Bruscoli, S., Bartoli, A., Cannarile, L., Migliorati, G., and Riccardi, C., 1997, A new Dexamethasone-induced gene of the leucin e zipper family protects T lymphocytes from TCR/CD3-activated cell death.Immunity7:803–812.

    Article  PubMed  Google Scholar 

  38. Cannarile, L., Zollo, O., D’Adamio, F., Ayroldi, E., Marchetti, C., Tabilio, A., bruscoli, S., and Riccardi, C., 2001, Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced geneCell Death and DifferentationPlenum Press.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Riccardi, C., Bruscoli, S., Ayroldi, E., Agostini, M., Migliorati, G. (2001). GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kB. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0685-0_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5194-8

  • Online ISBN: 978-1-4615-0685-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics