Statins as immunomodulatory drugs
Statins (inhibitors of HMG-ConA reductase) are widely used as cholesterol-lowering agents and have beneficial action in patients with complications of atherosclerosis (coronary disease). In addition, recent data indicate that they can also modulate a variety of other biological processes inhibiting neointimal proliferation, reducing inflammation and stimulating osteogenesis (1 2 3). Moreover, our preliminary studies point to the role of statins as potential immunosuppressive agents (4). In this report, we confum and extend those initial observations.
KeywordsMeasle Virus Human Recombinant Erythropoietin Immunomodulatory Drug Renal Allograft Rejection Plaque Form Cell
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