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Statins as immunomodulatory drugs

  • Andrzej Górski
  • Monika Kasprzycka
  • Maria Nowaczyka
  • Piotr Wierzbicki
  • Grażyna Korczakkowalskaa
  • Pawel Jezaka
  • Danuta Kłosowska
  • Aneta Ekierta
  • Konrad Kłodos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

Statins (inhibitors of HMG-ConA reductase) are widely used as cholesterol-lowering agents and have beneficial action in patients with complications of atherosclerosis (coronary disease). In addition, recent data indicate that they can also modulate a variety of other biological processes inhibiting neointimal proliferation, reducing inflammation and stimulating osteogenesis (1 2 3). Moreover, our preliminary studies point to the role of statins as potential immunosuppressive agents (4). In this report, we confum and extend those initial observations.

Keywords

Measle Virus Human Recombinant Erythropoietin Immunomodulatory Drug Renal Allograft Rejection Plaque Form Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Andrzej Górski
    • 1
    • 2
  • Monika Kasprzycka
    • 1
  • Maria Nowaczyka
    • 1
  • Piotr Wierzbicki
    • 1
  • Grażyna Korczakkowalskaa
    • 1
  • Pawel Jezaka
    • 1
  • Danuta Kłosowska
    • 1
  • Aneta Ekierta
    • 1
  • Konrad Kłodos
    • 1
  1. 1.Department of Clinical ImmunologyTransplantation Institute, The Medical University of WarsawWarsawPoland
  2. 2.L.Hirszfeld Institute ofImmunology and Experimental TherapyPolish Academy of SciencesWarsawPoland

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