Total body irradiation before bone marrow transplantation: aims and results

  • Julian Malicki
  • Jacek Wachowiak
  • Grażyna Kosicka
  • Grażyna Stryczyńska
  • Agnieszka Nowak
  • Jacek Pracz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)


Total Body Irradiation (TBI) is a procedure performed during the treatment of some disseminated malignancies in patients undergoing bone marrow transplantationl23456,2sTBI has three aims to meet: first, to reduce the population of neoplastic cells, second, to induce immunosupression, and third, to eradicate the recipient’s existing marrow cells so as to create room for newly transplanted marrowl789


Bone Marrow Transplantation Total Body Irradiation Calculated Dose Body Midline Reporting Photon Beam Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barret, A., 1999, Total body irradiation. R. Pract. Oncol. Radiothher 4(3):47–64.CrossRefGoogle Scholar
  2. 2.
    Cosset, J.M., Baume, D., Pico, J.L., Shank, B., Girinski, T., Banhamou, E., Briot, E., Malaise, E., Hayat, M., Dutreix, J., 1989, Single dose versus hyperfractionated total body irradiation before allogeneic bone marrow transplantation: a non-randomized comparative study of 54 patients at the Institute Gustave-Roussy. Radiother. Oncol 15: 151. 60.Google Scholar
  3. 3.
    Cosset, J.M., Girinski, T., Maloise, E., Chaillet, M.P., Dutreix, J., 1990, Clinical basis for TBI fractionation. Radiother. Oncol. Suppl 18: 60–68.Google Scholar
  4. 4.
    Inoue, T., Ikeda, H., Yamazaki, H., 1993, Role of total body irradiation as based on comparison of preparation regimens for allogene bone marrow transplantation for acute leukemia in first complete remission. Strahlenther. Onkol 169: 250. 55.Google Scholar
  5. 5.
    Kolb, H.J., Graitiwohl, A., Zwaan, F.E., 1988, Randomized study comparing busulfan and cyclophosphamide with total body irradiation with cyclophoshamide as conditioning treatment or allogemeic bone marrow transplantation patients with leukemia. Protocol of Acute Leukemia Working Party. European Cooperative Group for Bone Marrow Transplantation (EBMT)Google Scholar
  6. 6.
    Girinsky, T., Benhamou, E., Bourhis, J.H., Dhermain, F., Guillot-Valls, D., Ganansia, V., Luboinski, M., Perez, A., Cosset, J.M., Socie, G., Baume, D., Bouaouina, N., Briot, E., Beaudre, A., Bridier, A., Pico, J.L., 2000, Prospective randomized comparison of single-dose versus hyperfraction body irradiation in patients with hematologic malignancies. J. Clin. Oncol, 18: 981. 86.Google Scholar
  7. 7.
    Wachowiak, J., Boruczkowski, D., Malicki, J., Kaczmarek-Kanold, M., ChobotMusialkiewicz, U., Radwanska, U., 1999, Allogeneic bone marrow transplantation in children — eight years experience of paediatric BMT unit in Poznañ. Bone Marrow Transplant Suppl: 63.66.Google Scholar
  8. 8.
    Wachowiak, J., Boruczkowski, J., Malicki, J., Chobot-Musialkiewicz, U., 1998, Early post-BMT liver function in children with acute leukemia conditioned for allo-BMT with busulfan-containing and with FTBI-containing preparative regimens. Bone Marrow Transplant Suppl: 96. 99.Google Scholar
  9. 9.
    Sanchez-Doblado, F., Quast, V., Arrians, R., Errazquin, L., Sanchez-Nieto, B., Terron, J.A., 1995, Total body irradiation prior to bone marrow transplantation. EBMTGoogle Scholar
  10. 10.
    Quast, U., 1990, Total body irradiation — review of treatment techniques in Europe. Radiother. Oncol Suppl: 158. 62.Google Scholar
  11. 11.
    Quast, U., 1991, Physical problems of total body irradiation. Strahlenther. Onkol. 167: 135. 57.Google Scholar
  12. 12.
    Malicki, J., 1998, Doses in critical organs during total body irradiation before bone marrow transplantation. An. Ttransplant 3: 14–19.Google Scholar
  13. 13.
    American Association of Physicist in Medicine (AAPM). 1986, The physical aspects of total and half body photon irradiation. AAPM Report No. 17Google Scholar
  14. 14.
    Malicki, J., 1999, The accuracy of dose determination during total body irradiation. Strahlenther. Onko l 175: 492. 96.Google Scholar
  15. 15.
    Malicki, J., 1998, Doses in critical organs during total body irradiation before bone marrow transplantation. An. Ttransplant 3: 14–19.Google Scholar
  16. 16.
    Malicki, J., 1997, Beam filter and compensators during total body irradiation on Cobalt-60. R. Pract.Oncol. Radiother 2: 77. 81.Google Scholar
  17. 17.
    Malicki, J., Kosicka, G., Kierzkowski, J., Górny, A., 1996, An analysis of effectiveness and accuracy of ionization, semiconductor and thermoluminescent detectors used in total body irradiation. J. Med. Phys 21: 10. 13.Google Scholar
  18. 18.
    International Commission on Radiation Units and Measurements (ICRU). 1993, Prescribing, recording, and reporting photon beam therapy. ICRU Report 50Google Scholar
  19. 19.
    International Commission on Radiation Units and Measurement (ICRU). 1976,Determination of absorbed dose in a patient irradiated by beams of X or gamma rays in radiotherapy procedures. ICRU Report 24Google Scholar
  20. 20.
    Christ, G., Well, F., Nüsslin, F., 1991, In-vivo dosimetry in the thorax region at total body irradiation. Strahlenther. Onkol 167 (3): 148. 50.Google Scholar
  21. 21.
    Heukelom, S., Lanson, J.H., Mijneer, B.J., 1991, Comparison of entrance and exit dose measurements using ionization chambers and silicon diodes. Phys. Med. Biol 36 (I): 4759.Google Scholar
  22. 22.
    Jones, D., Rieke, J.W., Madsen, B.L., Hafermann, M.D., 2000, An isocentrically mounted stand for total body irradiation. Br. J. Radiol 73: 776. 69.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Julian Malicki
    • 1
  • Jacek Wachowiak
    • 3
  • Grażyna Kosicka
    • 1
  • Grażyna Stryczyńska
    • 2
  • Agnieszka Nowak
    • 1
  • Jacek Pracz
    • 4
  1. 1.Medical Physics DepartmentPoland
  2. 2.Radiotherapy DepartmentGreatPoland Cancer CentrePoznańPoland
  3. 3.BMT Unit, Clinic of Paediatric Oncology and HeamatologyUniversity of Medical SciencesPoznańPoland
  4. 4.Soltan Institute for Nuclear StudiesPoland

Personalised recommendations