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Adoptive transfer of mucosal T cells or dendritic cells from animals fed with cholera toxin B subunit alloantigen conjugate induces allogeneic T cell tolerance

  • Bin-Ling Li
  • Jia-Bin Sun
  • Jan Holmgren
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

Repeated oral administration of allogeneic antigens (allo-Ag) in animals has been shown to delay rejection of cardiac allografts (1). However, oral tolerance induction by feeding allo-Ag is known to be ineffective to prevent rejection of full allogeneic grafts (1). We have previously found that oral administration of various antigens conjugated to the mucosa-binding molecule cholera toxin B subunit (CTB) can most effectively induce antigen-specific peripheral T cell tolerance (2), and also suppress several autoimmune diseases in experimental models (3). More recently, we and others reported that oral administration of a single dose of allogeneic antigens (allo-Ag) conjugated to CTB significantly prolongs murine allograft survival and inhibits the mixed lymphocyte reactions (MLR), allo-Ag-specific delayed-type hypersensitivity (DTH), as well as cell-mediated cytotoxicity (4 5).

Keywords

Dendritic Cell Myelin Basic Protein Cholera Toxin Adoptive Transfer Mesenteric Lymph Node 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Bin-Ling Li
    • 1
  • Jia-Bin Sun
    • 1
  • Jan Holmgren
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyGöteborg UniversityGöteborgSweden

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