Abstract
Repeated oral administration of allogeneic antigens (allo-Ag) in animals has been shown to delay rejection of cardiac allografts (1). However, oral tolerance induction by feeding allo-Ag is known to be ineffective to prevent rejection of full allogeneic grafts (1). We have previously found that oral administration of various antigens conjugated to the mucosa-binding molecule cholera toxin B subunit (CTB) can most effectively induce antigen-specific peripheral T cell tolerance (2), and also suppress several autoimmune diseases in experimental models (3). More recently, we and others reported that oral administration of a single dose of allogeneic antigens (allo-Ag) conjugated to CTB significantly prolongs murine allograft survival and inhibits the mixed lymphocyte reactions (MLR), allo-Ag-specific delayed-type hypersensitivity (DTH), as well as cell-mediated cytotoxicity (4 5).
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Li, BL., Sun, JB., Holmgren, J. (2001). Adoptive transfer of mucosal T cells or dendritic cells from animals fed with cholera toxin B subunit alloantigen conjugate induces allogeneic T cell tolerance. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_37
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DOI: https://doi.org/10.1007/978-1-4615-0685-0_37
Publisher Name: Springer, Boston, MA
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