Gene transfer of protective cytokines in rheumatoid arthritis

  • Oliver Distler
  • Christiana Seemayer
  • Thomas Pap
  • Renate E. Gay
  • Michel Neidhart
  • Ulf Müller-Ladner
  • Steffen Gay
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)


Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting the joints resulting in their progressive destruction and in significant morbidity in the individual patient. Although the course of the disease is variable, the cumulative prevalence of work disability is as high as 50% at 10 years after onset of the disease (1). Considering that the prevalence of rheumatoid arthritis among adults has recently been estimated to be 10 per 1000 in the US, and that rheumatoid arthritis affects patients often in their most productive years, the socio-economic consequences for both the individual patient and society are severe (2).


Rheumatoid Arthritis Synovial Fibroblast Cartilage Degradation Human Cartilage Rheumatoid Arthritis Synovial Fibroblast 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Oliver Distler
    • 1
  • Christiana Seemayer
    • 1
  • Thomas Pap
    • 1
  • Renate E. Gay
    • 1
  • Michel Neidhart
    • 1
  • Ulf Müller-Ladner
    • 2
  • Steffen Gay
    • 1
  1. 1.WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic DiseasesUniversity Hospital ZurichSwitzerland
  2. 2.Department of Internal Medicine IUniversity of RegensburgGermany

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