Effect of Hsp70-peptide complexes generated in vivo on modulation EAE
Heat shock proteins (Hs;ps) are a family of proteins that are constitutively expressed by eukaryotic cells. They act as molecular chaperones, participating in intracellular translocation of proteins and enabling proper folding of polypeptide chains. It is postulated that unique chaperoning properties of Hsps might contribute to generating specific immune responses against peptides bound to theme’2. Many studies have demonstrated that Hsps isolated from cancer or viral infected cells elicit antitumor or antiviral immune response. However, Hsps derived from normal cells did not shown such effect3’4.It has been suggested that peptides associated with Hsps are responsible for this specific immunogenecity5.
KeywordsHeat Shock Protein Experimental Autoimmune Encephalomyelitis Healthy Mouse Experimental Autoimmune Encephalomyelitis Mouse Nonobese Diabetic Mouse
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