The role of Fc receptors and complement in autoimmunity

  • Ulrich Baumann
  • Reinhold E. Schmidt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)


IgG-autoantibodies are encountered in a number of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus

cryoglobulinaemia, autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura or hypersensitivity pneumonitis’“’. The involvement of autoantibodies in the pathogenesis of autoimmune diseases, however, is far from fully understood.


Mast Cell Idiopathic Thrombocytopenic Purpura Autoimmune Haemolytic Anaemia Classical Complement Pathway Bone Marrow Derive Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Korganow, A.S., Ji, H., Mangialaio, S., Duchatelle, V., Pelanda, R., Martin, T., Degott, C., Kikutani, H., Rajewski, K., Pasquali, J.L., Benoist, C., and Mathis, D., 1999, From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins.Immunity10:451–461PubMedCrossRefGoogle Scholar
  2. 2.
    Madaio, M.P., 1999, The role of autoantibodies in the pathogenesis of lupus nephritis.Semin.Nephrol.19:48–56PubMedGoogle Scholar
  3. 3.
    Ambrus, J.L.J., and Sridhar, N.R., 1997, Immunologic aspects of renal disease.JAMA278:1938–1945PubMedCrossRefGoogle Scholar
  4. 4.
    Dispenzieri, A., and Gorevic, P.D., 1999, Cryoglobulinemia.Hematol.Oncol.Clin North Am13:1315–1349PubMedCrossRefGoogle Scholar
  5. 5.
    Engelfriet, C.P., Overbeeke, M.A., and von dem Borne AE., 1992, Autoimmune hemolytic anemia.Semin.Hematol.29:3–12PubMedGoogle Scholar
  6. 6.
    Schmidt, R.E., Budde, U., Schafer, G., and Stroehmann, I., 1981, High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura.Lancet2:475–476PubMedCrossRefGoogle Scholar
  7. 7.
    Ando, M., and Suga, M., 1997, Hypersensitivity pneumonitis.Curr.Opin.Pulm.Med.3:391–395PubMedCrossRefGoogle Scholar
  8. 8.
    Gessner, J.E., Heiken, H., Tamm, A., and Schmidt, R.E., 1998, The IgG Fc receptor family.Ann. Hematol.76:231–248PubMedCrossRefGoogle Scholar
  9. 9.
    Köhl, J., and Gessner, J.E., 1999, On the role of complement and Fcgamma-receptors in the Arthus reaction.Mol.lmmunol.36:893–903CrossRefGoogle Scholar
  10. 10.
    Arthus M., 1903, Injections r¨¦p¨¦t¨¦es de s¨¦rum de cheval chez le lapin.Soc.Biol.55:817–825Google Scholar
  11. 11.
    Janeway, C.A. and P. Travers. 1997.Immunobiology. The immune system in health and disease.Current Biology/Garland Publishing, London/New YorkGoogle Scholar
  12. 12.
    Sylvestre, D.L., and Ravetch, J.V., 1994, Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade.Science265: 1095–1098PubMedCrossRefGoogle Scholar
  13. 13.
    Sylvestre, D.L., and Ravetch, J.V., 1996, A dominant role for mast cell Fc receptors in the Arthus reaction.Immunity.5:387–390PubMedCrossRefGoogle Scholar
  14. 14.
    Bozic, C.R., Lu, B., Höpken, U.E., Gerard, C., and Gerard, N.P., 1996, Neurogenic amplification of immune complex inflammation.Science273:1722–1725PubMedCrossRefGoogle Scholar
  15. 15.
    Höpken, U.E., Lu, B., Gerard, N.P., and Gerard, C., 1997, Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor.J Exp Med186:749–756PubMedCrossRefGoogle Scholar
  16. 16.
    Baumann, U., Köhl, J., Tschernig, T., Schwerter-Strumpf, K., Verbeek, J.S., Schmidt, R.E., and Gessner, J.E., 2000, A Codominant Role of FcgammaRI/III and C5aR in the Reverse Arthus Reaction.Jlmmunol.164:1065–1070Google Scholar
  17. 17.
    Heller, T., Gessner, J.E., Schmidt, R.E., Klos, A., Bautsch, W., and Köhl, J., 1999, Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis.Jlmmunol.162:5657–5661Google Scholar
  18. 18.
    Schiller, C., Janssen-Graalfs, I.R., Baumann, U., Schwerter-Strumpf, K., Izui, S., Takai, T., Schmidt, R.E., and Gessner, J.E., 2000, Mouse FcgammaRll is a negative regulator of FcgammaRlll in IgG immune complex triggered inflammation but not in autoantibody induced hemolysis.Eur.Jlmmunol.30:481–490CrossRefGoogle Scholar
  19. 19.
    Meyer, D., Schiller, C., Westermann, J., Izui, S., Hazenbos, W.L., Verbeek, J.S., Schmidt, R.E., and Gessner, J.E., 1998, FcgammaRlll (CD16)-deficient mice show IgG isotypedependent protection to experimental autoimmune hemolytic anemia.Blood92:3997–4002PubMedGoogle Scholar
  20. 20.
    Fossati-Jimack, L., Ioan-Facsinay, A., Reininger, L., Chicheportiche, Y., Watanabe, N., Saito, T., Hofhuis, F.M., Gessner, J.E., Schiller, C., Schmidt, R.E., Honjo, T., Verbeek, J.S., and Izui, S., 2000, Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.JExp.Med.191:1293–1302CrossRefGoogle Scholar
  21. 21.
    Watanabe, N., Akikusa, B., Park, S.Y., Ohno, H., Fossati, L., Vecchietti, G., Gessner, J.E., Schmidt, R.E., Verbeek, J.S., Ryffel, B., Iwamoto, I., Izui, S., and Saito, T., 1999, Mast Cells Induce Autoantibody-Mediated Vasculitis Syndrome Through Tumor Necrosis Factor Production Upon Triggering Fcgamma Receptors.Blood94:3855–3863PubMedGoogle Scholar
  22. 22.
    Deo, Y.M., Graziano, R.F., Repp, R., and van de Winkel JG., 1997, Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies.Immunol.Today18:127–135PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Ulrich Baumann
    • 1
  • Reinhold E. Schmidt
    • 1
  1. 1.Department of Clinical ImmunologyHanover Medical SchoolHannoverGermay

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