Cytokine-mediated growth inhibition of human melanoma cells
Interleukin-(IL)-6 and oncostatin M (OSM), closely related cytokines sharing gp130 as a common receptor signal transducing subunit’, are known for their antiproliferative action on melanocytes2and melanoma cells from early phases of tumor growth3’4. In contrast, cells from advanced stage melanomas in most cases acquire a so called “multicytokine resistance” phenotype becoming unresponsive to several cytokines including IL-6 and/or OSM. Therefore, it seems plausible that local paracrine growth inhibition plays an important role for the prevention of the firstin situstages of melanoma development. We and others suggest that in the case of melanoma cells Jak/STAT signaling can be critical for the negative regulation of their growths’6
KeywordsA375 Cell Melanoma Cell Human Melanoma Cell Human Melanoma Cell Line Chimeric Receptor
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- 6.Kortylewski, M., Heinrich, P. C., Mackiewicz, A., Schniertshauer, U., Klingmuller, U., Nakajima, K., Hirano, T., Horn, F., Behrmann, I., 1999, Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kipl.Oncogene18:3742–53.PubMedCrossRefGoogle Scholar
- 7.Gerhartz, C., Heesel, B., Sasse, J., Hemmann, U., Landgraf, C., Schneider-Mergener, J., Horn, F., Heinrich, P.C., Graeve, L., 1996, Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130.JBiol Chem271:12991–8.CrossRefGoogle Scholar
- 13.Jafari, M., Papp, T., Kirchner, S., Diener, U., Henschler, D., Burg, G., Schiffmann, D., 1995, Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma.J Cancer Res Clin Oncol121:23–30.PubMedCrossRefGoogle Scholar