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Cytokine-mediated growth inhibition of human melanoma cells

  • Marcin Kortylewski
  • Peter C. Heinrich
  • Andrzej Mackiewicz
  • Iris Behrmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

Interleukin-(IL)-6 and oncostatin M (OSM), closely related cytokines sharing gp130 as a common receptor signal transducing subunit’, are known for their antiproliferative action on melanocytes2and melanoma cells from early phases of tumor growth34. In contrast, cells from advanced stage melanomas in most cases acquire a so called “multicytokine resistance” phenotype becoming unresponsive to several cytokines including IL-6 and/or OSM. Therefore, it seems plausible that local paracrine growth inhibition plays an important role for the prevention of the firstin situstages of melanoma development. We and others suggest that in the case of melanoma cells Jak/STAT signaling can be critical for the negative regulation of their growths6

Keywords

A375 Cell Melanoma Cell Human Melanoma Cell Human Melanoma Cell Line Chimeric Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Marcin Kortylewski
    • 1
    • 2
  • Peter C. Heinrich
    • 1
  • Andrzej Mackiewicz
    • 2
  • Iris Behrmann
    • 1
  1. 1.Department of BiochemistryRWTH AachenGermany
  2. 2.Department of Cancer Immunology at GreatPoland Cancer CenterUniversity School of Medical SciencesPoznanPoland

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