Abstract
The family of Interleukin-6(IL-6)-type cytokines comprises IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and the recently described novel neurotrophin-1/B-cell stimulatory factor 3/cardiotrophin-1-like cytokine. These cytokines play an important role in hematopoiesis, inflammation, the acute phase response, and bone and heart development as well as neurogenesis. The redundant effects can be attributed to the shared use of the common signal transducing receptor chain glycoprotein (gp) 130. Gp130 is homodimerized by IL-6 and IL-I I upon binding to their ligand-specific a-receptors. The other cytokines of this family trigger the heterodimerization of gp130 with LIF receptor (LIF-R) or the OSM-specific receptor (OSM-R).
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Heinrich, P.C. et al. (2001). Termination and modulation of IL-6-type cytokine signaling. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_20
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DOI: https://doi.org/10.1007/978-1-4615-0685-0_20
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