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Termination and modulation of IL-6-type cytokine signaling

  • Peter C. Heinrich
  • Johannes Bode
  • Manuela Decker
  • Lutz Graeve
  • Astrid Martens
  • Gerhard Müller-Newen
  • Stefan Pflanz
  • Fred Schaper
  • Jochen Schmitz
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

The family of Interleukin-6(IL-6)-type cytokines comprises IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) and the recently described novel neurotrophin-1/B-cell stimulatory factor 3/cardiotrophin-1-like cytokine. These cytokines play an important role in hematopoiesis, inflammation, the acute phase response, and bone and heart development as well as neurogenesis. The redundant effects can be attributed to the shared use of the common signal transducing receptor chain glycoprotein (gp) 130. Gp130 is homodimerized by IL-6 and IL-I I upon binding to their ligand-specific a-receptors. The other cytokines of this family trigger the heterodimerization of gp130 with LIF receptor (LIF-R) or the OSM-specific receptor (OSM-R).

Keywords

Cytoplasmic Tail Ciliary Neurotrophic Factor Redundant Effect Leukemia Inhibitory Factor Receptor Constitutive Internalization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Peter C. Heinrich
    • 1
  • Johannes Bode
    • 1
  • Manuela Decker
    • 1
  • Lutz Graeve
    • 1
  • Astrid Martens
    • 1
  • Gerhard Müller-Newen
    • 1
  • Stefan Pflanz
    • 1
  • Fred Schaper
    • 1
  • Jochen Schmitz
    • 1
  1. 1.Department of BiochemistryTechnical University RWTH Aachen, Pauwelsstraβe 30AachenGermany

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