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Coordination of interleukin-6 biology by membrane bound and soluble receptors

  • Stefan Rose-John
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

On target cells IL-6 first binds to the IL-6 receptor (IL-6R). The complex of IL-6 and IL-6R associates with the signaltransducing membrane protein gp130, thereby inducing its dimerization and initiation of signaling. gp130 is expressed by all cells in the body whereas IL-6R is mainly expressed by hepatocytes, monocytes/macrophages and lymphocytes. A naturally occurring soluble form of the IL-6R (sIL-6R), which has been found in various body fluids, is generated by two independent mechanisms, limited proteolysis of the membrane protein and translation from an alternatively spliced mRNA2. Interestingly, the sIL-6R together with IL-6 stimulates cells which only express gp 13034a process which has been named transsignaling25. Recently, it has been shown that the sIL-6R strongly sensitizes target cells6. Early hematopoietic progenitor cells57many neural cells“, smooth muscle cells and endothelial cells’1among others, are only responsive to IL-6 in the presence of sIL-6R12.

Keywords

Hematopoietic Progenitor Cell Soluble Receptor Lamina Propria Mononuclear Cell Soluble Cytokine Receptor Human Hematopoietic Progenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Stefan Rose-John
    • 1
  1. 1.Department of Biochemistry, Christian-Albrechts-Universität zu KielOslhausenstr. 40KielGermany

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