Effect of polysaccharide sulfates on the production of interleukin-8 in an ex vivo model
Bacterial infections as well as immunological diseases result in activation of various endogenous mediators including cytokines (1). One of these cytokines is interleukin-8 (IL-8) which attracts neutrophils, basophils and T-cells, induces adherence to vascular endothelium and extravasation into tissue spaces (1). It has been evidenced that the levels of IL-8 in body fluids are elevated in the patients with inflammatory diseases: cardiac failure, rheumatoid arthritis, and infections of the renal, pulmonary, and urinary tracts (2, 3). IL-8 belongs to C-X-C chemokine family and is produced by a variety of cell types, including endothelial cells, hepatocytes, keratinocytes and monocyte-derived macrophages in response to lipopolysaccharides and inflammatory cytokines: tumor necrosis factor alpha (TNF-a) and IL-1 (1,4). Numerous medicines have been used to stimulate the immune system. The root of Panax ginseng had been known in East Asia, as an elixir, used as an antiseptic, stomachic, tonic and sedative drug for thousands of years (5). It has recently been reported that acidic polysaccharides extracted from the root of Panax ginseng, stimulate IL-8 synthesis in monocyte-derived macrophages and may augment the activation and chemotaxis of neutrophils in the incidence of sepsis (5).
KeywordsPanax Ginseng Concentration Of30 Acidic Polysaccharide Chemokine Family Endogenous Mediator
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