Major histocompatibility complex class II (MHC II) expression during development of human fetal brain and haemopoietic organs
Proteins of the major histocopatibility complex class II molecules (MHC II, HLA II, Ia) are surface glycoproteins of cellular membrans. They are products of HLA-DP, HLA-DQ and HLA-DR genes, encoded on at least 100 genes. Molecules of MHC II antigen belong to the most polymorphic proteins among those recognized to date1-3. Polymorphism of both genes and MHC proteins, resulting from the evolution process, ensures that many different peptides are bound, hence the organisms are capable to specific immune response. The molecules of this system are responsible for the binding, transport, and presentation of a forein antigen to helper T lymphocytes (Th, CD4). They also stimulate the multiplication of specific B lymphocytes and determine the type of antibodies produced4-6. Another important feature of their responsibility is participation in the selection, leading to differentiation of immature into mature lymphocytes. In adult, MHC II molecules are expressed on the surface of cells identified as antigen-presenting cells (APCs); macrophages, B lymphocytes, microglial and dendritic cells. In developing organisms, MHC II expression is also observed on other types of cells: on vascular endothelium, thymic epithelial ce11s7-9.
KeywordsDendritic Cell Major Histocompatibility Complex Human Fetal Brain Major Histocompatibility Complex Protein Ricinus Communis Agglutinin
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