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Major histocompatibility complex class II (MHC II) expression during development of human fetal brain and haemopoietic organs

  • Teresa Wierzba-Bobrowicz
  • Elżbieta Kosno-Kruszewska
  • Eliza Lewandowska
  • Waldemar Lechowicz
  • Bogna Schmidt-Sidor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)

Abstract

Proteins of the major histocopatibility complex class II molecules (MHC II, HLA II, Ia) are surface glycoproteins of cellular membrans. They are products of HLA-DP, HLA-DQ and HLA-DR genes, encoded on at least 100 genes. Molecules of MHC II antigen belong to the most polymorphic proteins among those recognized to date1-3. Polymorphism of both genes and MHC proteins, resulting from the evolution process, ensures that many different peptides are bound, hence the organisms are capable to specific immune response. The molecules of this system are responsible for the binding, transport, and presentation of a forein antigen to helper T lymphocytes (Th, CD4). They also stimulate the multiplication of specific B lymphocytes and determine the type of antibodies produced4-6. Another important feature of their responsibility is participation in the selection, leading to differentiation of immature into mature lymphocytes. In adult, MHC II molecules are expressed on the surface of cells identified as antigen-presenting cells (APCs); macrophages, B lymphocytes, microglial and dendritic cells. In developing organisms, MHC II expression is also observed on other types of cells: on vascular endothelium, thymic epithelial ce11s7-9.

Keywords

Dendritic Cell Major Histocompatibility Complex Human Fetal Brain Major Histocompatibility Complex Protein Ricinus Communis Agglutinin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Blaszczyk, R., Wehling, J., Kubens, B., Hahn, U., Huhn, D., Salama, A. 1995, A novel HLA-A-24 allele (A 2405) identified by single —strand conformation polymorphism analysis and confirmed by solid-phase sequencing and isoelectric focusing.Tissue Antigens 46: 54–58.CrossRefGoogle Scholar
  2. 2.
    Castellino, F., Zhong, G., Germain, R.N. 1997, Antigen presentation by MHC classIImolecules: invariant chain function, protein trafficking and the molecular basis of diverse determinant capture.Hum Immunol 54: 159–69.PubMedCrossRefGoogle Scholar
  3. 3.
    Engering, A.J., Richters, C.D., Fluitsma, D.M., et al., 1998, MHC II class II and invariant chain biosynthesis and transport during maturation of human precursor dendritic cells.Int Immunol 10: 1713–1723.PubMedCrossRefGoogle Scholar
  4. 4.
    Gehrmann, J., Matsumoto, Y., Kreutzberg, G.W., 1995, Microglia: intrinsic immunoneffector cell of the brain.Brain Res20: 269–287.CrossRefGoogle Scholar
  5. 5.
    Mc Menamin, P.G., Holthouse, I., Holt, P.G., 1992, ClassIImajor histocompatibility complex (Ia) antigen bearing dendritic cells in the iris and ciliary of the rat eye: distribution, phenotype and relation to retinal microglia.Immunology77: 385–393.Google Scholar
  6. 6.
    Petranyi, G.G., 1995, The regulation of expression of histocompatibility antigens on the cell surface; molecular genetic basis.Folia Biol41: 163–177.Google Scholar
  7. 7.
    Keller, R., Joller, P., Keist, R., Binz, H., van der Meide, P.H., 1998, Modulation of major histocompatibility complex (MHC) expression by interferons and microbial agens.Scand J Immunol 28: 113–121.CrossRefGoogle Scholar
  8. 8.
    Pujol-Borrell, R., Todd, I., Doshi, M. et al., 1987, HLA class II induction in human island cells by interferon-y plus tumor necrosis factor or lymphotoxin.Nature 326: 304–306.PubMedCrossRefGoogle Scholar
  9. 9.
    Wang, C.C., Wu, C.H., Shieh, J.Y., Wen, C.Y., Ling, E.A., 1996, Immunohistochemical study of amoeboid microglial cells in fetal rat brain.JAnat 189: 567–574.Google Scholar
  10. 10.
    Banati, R.B., Hoppe, D., Gottmann, K., Kreutzberg, G.W., Kettenmann, H., 1991, A subpopulation of bone marrow-derived macrophage-like cells shares a unique oin channel pattern with microglia.JNeurosci Res 30: 593–600.CrossRefGoogle Scholar
  11. 11.
    Wierzba-Bobrowicz, T., Kosno-Kruszewska, E., Gwiazda, E., Lechowicz, W., 1998, The comparison of microglia maturation in different structures of the human nervous system.Folia Neuropath 36: 152–160.Google Scholar
  12. 12.
    Brocker, T., Riedinger, M., Karjalainen, U., 1997, Targeted expression of major histocompatibility complex (MHC) classIImolecules demonstrates that dendriric cells can induce negative but not positive selection of thymocytes in vivo.J Exp Med 185: 541–550.PubMedCrossRefGoogle Scholar
  13. 13.
    Cuadros, M.A., Martin, C., Coltay, P., Almedros, A., Navascues, J., 1993, First appesrance, distribution, and origin of macrophages in the early development of the avian central nervous system.JComp Neurol330: 113–129.CrossRefGoogle Scholar
  14. 14.
    Giulian, D., Li, J., Bartel, S., Broker, J., Li, X., Kirkpatrick, J.B., 1995, Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte.J Neurosci 15: 7712–7726.PubMedGoogle Scholar
  15. 15.
    Ling, E.A., 1979, Transformation of monocytes into amoeboid microglia and into microglia in the corpus callosum of postnatal rats, as shown by labelling monocytes by carbon particles.JAnat 128: 847–858.Google Scholar
  16. 16.
    Wierzba-Bobrowicz, T., Schmidt-Sidor, B., Gwiazda, E., Lechowicz, W., KosnoKruszewska, E., 2000, Major histocompatibility complex class II expression in the frontal and temporal lobes in the human fetus during development.Folia Neuropath 38: 73–77.Google Scholar
  17. 17.
    Ashwell, K., 1991, The distribution of microglia and cell death in the fetal rat forebrain.Dey Brain Res 58: 1–12.CrossRefGoogle Scholar
  18. 18.
    Rescigno, M., Martino, M., Sutherland, C.L., Gold, M.R., Ricciardi-Castagnoli, P., 1998, Dendritic cell survival and maturation are regulated by different singnaling pathway.JExp Med 188: 2175–80.CrossRefGoogle Scholar
  19. 19.
    Tan, M.C., Mommaas, A.M., Drijfhout, J.W. et al., 1997, Mannose receptor-mediated uptake of antigens strongly enhances HLA class II restricted antigen presentation by cultured dendritic cells.Eur Jlmmunol 27: 2426–2435.CrossRefGoogle Scholar
  20. 20.
    Hanau, D., Sandrais, C., Haegel-Kronenberger, H., Bohbot, A., De la Salle, H., Salamero, J., 1999, Fate of class MHCIImolecules in human dendritic cells.Eur JDermatol 9: 7–12.Google Scholar
  21. 21.
    Medzhitov, R., Janeway, C.A., Jr., 1997, Innate immunity:the virtues of a nonclonal system of a nonclonal system of recognition.Cell 91: 295–298.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Teresa Wierzba-Bobrowicz
    • 1
  • Elżbieta Kosno-Kruszewska
    • 1
  • Eliza Lewandowska
    • 1
  • Waldemar Lechowicz
    • 1
  • Bogna Schmidt-Sidor
    • 1
  1. 1.Department of NeuropathologyInstitute of Psychiatry and NeurologyWarsawPoland

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