The AIR-1 encoded class II transactivator (CIITA): the master coordinator of MHC class II gene expression and ..more

  • Roberto S. Accolla
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 495)


MHC class II genes encode highly polymorphic cell surface glycoprotein heterodimers that play a key role for the homeostasis of the immune response. Class II molecules expressed in appropriate antigen presenting cells (APC) act as receptors for antigenic peptides that only under this form can be presented to regulatory CD4+ T cells (TH) and trigger the cascade of events leading to both humoral and cellular immune effector functions (reviewed in 1).


Major Histocompatibility Complex Class Severe Combine Immunodeficiency Cellular Host Bacterial Phagocytosis Bare Lymphocyte Syndrome 
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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Roberto S. Accolla
    • 1
  1. 1.Department of Clinical and Biological Sciences, Chair of General Pathology and ImmunologySchool of Medicine, University of Insubria, Varese; and Istituto Nazionale per la Ricerca sul Cancro (1ST), Advanced Biotechnology CenterGenovaItaly

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