Role of tapasin in MHC class I antigen presentation in vivo
Antigen presentation on MHC class I molecules is a key event for CD8+T cell development as well as initiation and maintenance of immunological responses against intracellular microorganisms. For a cellular immune response to be initiated, peptides derived from invading pathogens need to be generated, loaded onto MHC class I molecules in the endoplasmic reticulum (ER) and displayed at the cell surface for CD8+ T cell recognition1,2. The generation of antigenic peptides is usually achieved by proteolytic degradation in the cytosol by the proteasome. Peptides are then selectively transported into the ER lumen by the transporter associated with antigen presentation (TAP) and loaded onto “peptide-receptive” class I molecules in a process assisted by several molecular chaperones and accessory proteins.
KeywordsAntigen Presentation Peptide Binding Endoplasmic Reticulum Lumen Surface Class Antigen Presentation Pathway
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