Toxins, Travels and Tropisms: H. pylori and Host Cells

  • Nina R. Salama
  • Stanley Falkow
  • Karen M. Ottemann
Part of the Infectious Agents and Pathogenesis book series (IAPA)


In this chapter we will discuss the ways in which H. pylori interacts with and manipulates host cells. Studies with H. pylori reveal a number of effects on host cells including attachment-induced membrane and cytoskeletal changes, disruption of endocytic traffic and vacuolation, alteration of transepithelial conductance, induction of proinflamatory cytokines, alteration of antigen processing, induction of cell migration, loss of mucus granules, arrest of cell cycle progression and induction of apoptosis. Molecular identification of bacterial factors responsible for a few of these effects has been achieved, but most remain H. pylori-associated phenotypes.


HeLa Cell Gastric Epithelial Cell Early Endosome Pylorus Strain Late Endosome 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Nina R. Salama
    • 1
  • Stanley Falkow
    • 1
  • Karen M. Ottemann
    • 2
  1. 1.Department of Microbiology and ImmunologyStanford UniversityStanfordUSA
  2. 2.Departments of Biology and Environmental ToxicologyUniversity of California at Santa CruzSanta CruzUSA

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