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Toxins, Travels and Tropisms: H. pylori and Host Cells

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Helicobacter pylori Infection and Immunity

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

In this chapter we will discuss the ways in which H. pylori interacts with and manipulates host cells. Studies with H. pylori reveal a number of effects on host cells including attachment-induced membrane and cytoskeletal changes, disruption of endocytic traffic and vacuolation, alteration of transepithelial conductance, induction of proinflamatory cytokines, alteration of antigen processing, induction of cell migration, loss of mucus granules, arrest of cell cycle progression and induction of apoptosis. Molecular identification of bacterial factors responsible for a few of these effects has been achieved, but most remain H. pylori-associated phenotypes.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA

    Nina R. Salama & Stanley Falkow

  2. Departments of Biology and Environmental Toxicology, University of California at Santa Cruz, Santa Cruz, CA, USA

    Karen M. Ottemann

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  1. Nina R. Salama
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  2. Stanley Falkow
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  3. Karen M. Ottemann
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  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Yoshimasa Yamamoto  & Herman Friedman  & 

  2. Dalhousie University, Halifax, Nova Scotia, Canada

    Paul S. Hoffman

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© 2002 Springer Science+Business Media New York

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Salama, N.R., Falkow, S., Ottemann, K.M. (2002). Toxins, Travels and Tropisms: H. pylori and Host Cells. In: Yamamoto, Y., Friedman, H., Hoffman, P.S. (eds) Helicobacter pylori Infection and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0681-2_11

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  • DOI: https://doi.org/10.1007/978-1-4615-0681-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5192-4

  • Online ISBN: 978-1-4615-0681-2

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