Neural Mechanisms of Communication: From Pheromones to Mosaic Signals

  • Robert E. Johnston


The purpose of this chapter is, first, to review concepts about the types of chemical signals that are used for communication, ranging from classic, single-compound pheromones to complex mixtures used for social recognition and, second, to summarize what we know about the neural mechanisms underlying responsiveness to these different types of signals in mammals. The specific examples come primarily from my own research and that of others on golden hamsters.


Sexual Arousal Golden Hamster Vaginal Secretion Main Olfactory Bulb Vomeronasal Organ 
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  1. Eichenbaum, H., Shedlack, K. J., and Eckmann, K. W., 1980, Thalamocortical mechanisms in odor-guided behavior I. Effects of lesions of the mediodorsal thalamic nucleus and frontal cortex on olfactory discrimination in the rat, Brain Behav. Evol. 17:255–275.PubMedCrossRefGoogle Scholar
  2. Eichenbaum, H., Clegg, R. A., and Feeley, A., 1983, Reexamination of functinal subdivisions of the rodent prefrontal cortex, Exp. Neurol. 79:434–451.PubMedCrossRefGoogle Scholar
  3. Jang, T., Singer, A. G., and Macrides, F., 1995, Induction of c-fos-gene product in the male hamster accessory olfactory bulbs by natural and bacterially cloned aphrodisin, Chem. Senses 20:712–713.Google Scholar
  4. Johnston, R. E., 1986, Effects of female odors on the sexual behavior of male hamsters, Behav. Neural Biol. 46:168–188.PubMedCrossRefGoogle Scholar
  5. Johnston, R. E., 1998, Pheromones, the vomeronasal system, and communication, Ann. NY Acad. Sci. 855:333–348.PubMedCrossRefGoogle Scholar
  6. Johnston, R. E., 2000, Chemical communication and pheromones:the types of signals and the role of the vomeronasal system, in: The Neurobiology of Taste and Smell, 2nd edition (T. E. Finger, W. L. Silver, and D. Restrepo, eds.), Wiley, New York, pp. 99–123.Google Scholar
  7. Johnston, R. E., and Peng, M., 2000, The vomeronasal organ is involved in discrimination of individual odors by males but not by females in golden hamsters, Physiol. Behav., 70: (in press).Google Scholar
  8. Johnston, R. E., and Rasmussen, K., 1984, Individual recognition of female hamsters by males: Role of chemical cues and of the olfactory and vomeronasal systems, Physiol. Behav. 33:95–104.PubMedCrossRefGoogle Scholar
  9. Johnston, R. E., and Zahorick, D. M., 1975, Taste aversions to sexual attractants, Science 189:893–894.PubMedCrossRefGoogle Scholar
  10. Johnston, R. E., Zahorick, D. M., Immler, K., and Zakon, H., 1978, Alterations of male sexual behavior by learned aversions to hamster vaginal secretion, J. Comp. Physiol. Psychol. 92:85–93.PubMedCrossRefGoogle Scholar
  11. Kaba, H., Rosser, A., and Keverne, E. B., 1989, Neural basis of olfactory memory in the context of pregnancy block, Neuroscience 32:657–662.PubMedCrossRefGoogle Scholar
  12. Keverne, E. B., 1998, Vomeronasal/accessory system and pheromonal recognition, Chem. Senses 23:491–494.PubMedCrossRefGoogle Scholar
  13. Keverne, E. B., 1999, The vomeronasal organ, Science 286:716–720.PubMedCrossRefGoogle Scholar
  14. Kwan, M., and Johnston, R. E., 1980, The role of vaginal secretion in hamsters sexual behavior: Males’ responses to normal and vaginectomized females and their odors, J. Comp. Physiol. Psychol. 94:905–913.PubMedCrossRefGoogle Scholar
  15. Linn, C. E., and Roelofs, W. L., 1989, Response specificity of male moths to multicomponent pheromones, Chem. Senses 14:421–437.CrossRefGoogle Scholar
  16. Macrides, F., Bartke, A., Fernandez, F., and D’Angelo, W., 1974, Effects of exposure to vaginal odor and receptive females on plasma testosterone in the male hamster, Neuroendocrinol. 15:355–364.CrossRefGoogle Scholar
  17. Meredith, M., 1986, Vomeronasal organ removal before sexual experience impairs male hamster mating behavior, Physiol. Behav. 36:737–743.PubMedCrossRefGoogle Scholar
  18. O’Connell, R. J., and Meredith, M., 1984, Effects of volatile and non-volatile chemical signals on male sex behaviors mediated by the main and accessory olfactory systems, Behav. Neurosci. 98:1083–1093.CrossRefGoogle Scholar
  19. Otto, T., and Eichenbaum, H., 1992, Olfactory learning and memory in the rat: A “model system” for studies of the neurobiology of memory, in: Science of Olfaction (M. J. Serby, and K. L. Chobor, eds.), Springer-Verlag, New York, pp. 213–244.Google Scholar
  20. Parkes, A. S., and Bruce, H. M., 1961, Olfactory stimuli in mammalian reproduction, Science 134:1049–1054.PubMedCrossRefGoogle Scholar
  21. Petrulis, A., and Johnston, R. E., 1995, A reevaluation of dimethyl disulfide as a sex attractant in golden hamsters, Physiol. Behav. 57:779–784.PubMedCrossRefGoogle Scholar
  22. Petrulis, A., and Johnston, R. E., 1999, Lesions centered on the medial amygdala impair scent-marking and sex-odor recognition but spare discrimination of individual odors in female golden hamsters, Behav. Neurosci. 113:345–357.PubMedCrossRefGoogle Scholar
  23. Petrulis, A., DeSouza, I., Schiller, M., and Johnston, R. E., 1998, Role of the frontal cortex in social odor discrimination and scent-marking in female golden hamsters (Mesocricetus aruatus), Behav. Neurosci. 112:199–212.PubMedCrossRefGoogle Scholar
  24. Petrulis, A., Peng, M., and Johnston, R. E., 1999a, Effects of vomeronasal organ removal on individual odor discrimination, sex-odor preference, and scent marking in female hamsters, Physiol. Behav. 66:73–83.PubMedCrossRefGoogle Scholar
  25. Petrulis, A., Peng, M., and Johnston, R. E., 1999b, Lateral olfactory tract transections impair discrimination of individual odors, sex odor preferences, and scent marking in female golden hamsters (Mesocricetus auratus), in: Advances in Chemical Signals in Vertebrates (R. E. Johnston, D. Müller-Schwarze, and P. W. Sorensen, eds.), Plenum Press, New York, pp. 549–561.Google Scholar
  26. Petrulis, A., Peng, M., and Johnston, R. E., 2000, The role of the hippocampal system in social odor discrimination and scent marking in female golden hamsters (Mesocricetus aruatus), Behav. Neurosci. 114:184–195.PubMedCrossRefGoogle Scholar
  27. Pfeiffer, C. A., and Johnston, R. E., 1994, Hormonal and behavioral responses of male hamsters to females and female odors: Roles of olfaction, the vomeronasal system, and sexual experience, Physiol. Behav. 55:129–138.PubMedCrossRefGoogle Scholar
  28. Powers, J. B., and Winans, S. S., 1975, Vomeronasal organ: critical role in mediating sexual behavior of the male hamster, Science 187:961–963.PubMedCrossRefGoogle Scholar
  29. Singer, A. G., Agosta, W. C., and Clancy, A. N., 1987, The chemistry of vomeronasally detected pheromones: Characterization of an aphrodisiac protein, Ann. N.Y. Acad Sci. 519:287–298.PubMedCrossRefGoogle Scholar
  30. Singer, A. G., Agosta, W. C., O’Connell, R. J., Pfaffmann, C., Bowen, D. V., and Field, F.H., 1976, Dimethyl disulphide: An attractant pheromone in hamster vaginal secretion, Science 191:948–950.PubMedCrossRefGoogle Scholar
  31. Singer, A. G., and Macrides, F., 1990, Aphrodisin: pheromone or transducer, Chem. Senses 15:199–203.CrossRefGoogle Scholar
  32. Whishaw, I. Q., Tomie, J.-A., and Kolb, B., 1992, Ventrolateral prefrontal cortex lesions in rats impair the acquisition and retention of a tactile-olfactory configural task, Behav. Neurosci. 106:597–603.PubMedCrossRefGoogle Scholar
  33. Winans, S. S., and Powers, J. B., 1977, Olfactory and vomeronasal deafferentation of male hamsters: histological and behavioral analyses, Brain Res. 126:325–344.PubMedCrossRefGoogle Scholar
  34. Wysocki, C. J., 1989, Vomeronasal chemoreception: its role in reproductive fitness and physiology, in: Neural Control of Reproductive Function (J. M. Lakoski, J. R. Perez-Polo, and D. K. Rassin, eds.), A. R. Liss, New York, pp. 545–566.Google Scholar
  35. Wysocki, C. J., and Meredith, M., 1987, The vomeronasal system, in: Neurobiology of Taste and Smell (T. E. Finger, and W. L. Silver, eds.), John Wiley and Sons, New York, pp. 125–150.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Robert E. Johnston
    • 1
  1. 1.Department of PsychologyCornell UniversityIthacaUSA

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