Heterogeneity of Major Urinary Proteins in House Mice: Population and Sex Differences
House mice (Mus domesticus) and rats (Rattus norvegicus) secrete large quantities of protein into their urine as the normal condition (Finlayson and Baumann, 1958). These proteins are major urinary proteins (MUP) and alpha2u-globulins respectively. Both are small proteins that have been assigned to the lipocalin protein family on the basis of sequence data (reviewed by Flower, 1996) and X-ray crystallography (Bocskei et al., 1992). As such, both display a typical lipocalin beta-barrel structure enclosing an internal cavity in which volatile ligands may bind.
KeywordsMajor Histocompatibility Complex House Mouse Laboratory Mouse Scent Mark Wild Mouse
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- Finayson, J. S., and Baumann, C. A., 1958, Mouse proteinuria, Am. J. Physiol. 192:69–72.Google Scholar
- Mucignat, C. C., Caretta, A., and Cavaggioni, A., 1995, Accelaration of puberty onset in female mice by male urinary proteins, J. Physiol. 486:517–522.Google Scholar
- Novotny, M. V., Ma, W., Zidek, L., and Daev, E., 1999a, Recent biochemical insights into puberty acceleration, estrus induction and puberty delay in the house mouse, in: Advances in Chemical Communication, (R. E. Johnston, D. Müller-Schwarze, and P. Sorenson, eds.), Plenum Press, New York, pp. 99–116.Google Scholar
- Pes, D., Robertson, D. H. L., Hurst, J. L., Gaskell, S. J., and Beynon, R. J., 1999, How many major urinary proteins are produced by the house mouse Mus domesticus?, in: Advances in Chemical Communication, (R. E. Johnston, D. Müller-Schwarze, and P. Sorenson, eds.), Plenum Press, New York, pp. 149–161.Google Scholar
- Triggs, G. S., 1991, The population ecology of house mice (Mus domesticus) on the Isle of May, Scotland, J. Zool. 206:286–291.Google Scholar
- Wicks, L. F., 1941, Sex and proteinuria of mice, Proc. Soc. Exp. Biol. Med. 48:395–400.Google Scholar
- Yamazaki, K., Beauchamp, G. K., Imai, Y., Bard, J., Thomas, L., and Boyse, E. A., 1992, MHC control of odortypes in the mouse, in: Chemical Signals in Vertebrates VI (R. L. Doty, and D. Müller-Schwarze, eds.), Plenum Press, New York, pp. 189–196.Google Scholar