Metabolism of R,S Enantiomers of 3-Phenylamino-1,2-Propanediol, a Compound Associated with the Toxic Oil Syndrome, in C57BL/6- and A/J-Strain Mice
The Toxic Oil Syndrome (TOS) appeared in Spain in spring 1981 as a massive food-borne intoxication in the central and northwestern areas of the country. A huge population of over 20,000 people was afflicted and over 400 deaths occurred1. The clinical features of TOS resembled an allergic-toxic syndrome in the acute phase and an autoimmune condition in the chronic phase1,2. Although some patients recovered after a long period of time (several months), many continue to suffer severe sequel or mild symptoms.
KeywordsAniline Derivative Aniline Hydrochloride World Health Organization Regional Intestinal Hydrolysis Radioactivity Clearance
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