Mechanisms of Ovotoxicity Induced by Environmental Chemicals: 4-Vinylcyclohexene Diepoxide as a Model Chemical
Females are born with a finite number of undeveloped, primordial follicles. Environmental chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopause in women) because once destroyed, they cannot be replaced. Menopause is known to be associated with an increased incidence of a variety of health problems such as osteoporosis, cardiovascular disease, and ovarian cancer. Exposure of women to chemicals that are ovotoxic in laboratory animals (chemotherapeutic agents, contaminants of cigarette smoke) is known to be associated with early menopause. Therefore, an overall understanding of mechanisms involved in chemical-induced ovotoxicity is of general health-related concern (Hoyer and Sipes, 1996).
KeywordsOsteoporosis Glutathione Rubber Polycyclic Aromatic Hydrocarbon Smoke
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- J.K. Doerr-Stevens, J. Liu, G.J. Stevens, J.C. Kraner, S.M. Fontaine, J.R. Halpert, and I.G. Sipes, Induction of cytochrome P-450 enzymes after repeated exposure to 4-vinylcyclohexene in B6C3F1 mice.Drug Metab. Disp27(2):281–287 (1999).Google Scholar
- W.L. Heinrichs, and M.R. Juchau, Extrahepatic drug metabolism: The gonads. In: Extrahepatic Metabolism of Drugs and Other Foreign Compounds, TE Gram (ed), SP Medical and Scientific Books, New York, pp. 319 (1980).Google Scholar
- A.N. Hirshfield, Development of follicles in the mammalian ovary. Int. Rev. Cytol. 124 (1991).Google Scholar
- H. Mukhtar, R.M. Philpot, and J.B. Bend, The postnatal development of microsomal epoxide hydrase, cytosolic glutathione S-transferase, and mitochondrial and microsomal cytochrome P-450 in adrenals and ovaries of female rats.Drug Metab. Disp.6:577 (1978a).Google Scholar
- National Toxicology Program, Toxicology and carcinogenesis studies of 4-vinylcyclohexene in F344/N rats and B6C3F1 mice. NTP Tec. Rep. No. 303US Dept. Health Hum. Serv. Public Health Serv. Natl. Inst. Health. Public Inf. Natl. Toxicol. Program, Research Triangle Park NC. (1986).Google Scholar
- K.L. Salyers, W. Zheng, and I.G. Sipes, Disposition and toxicokinetics of 4-vinyl-1-cyclohexene diepoxide in female F344 rats and B6C3F1 mice, ISSX Proc4:Abstract 169 (1993).Google Scholar