Mechanisms of Ovotoxicity Induced by Environmental Chemicals: 4-Vinylcyclohexene Diepoxide as a Model Chemical

  • Patricia B. Hoyer
  • Ellen A. Cannady
  • Nicole A. Kroeger
  • I. Glenn Sipes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 500)


Females are born with a finite number of undeveloped, primordial follicles. Environmental chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopause in women) because once destroyed, they cannot be replaced. Menopause is known to be associated with an increased incidence of a variety of health problems such as osteoporosis, cardiovascular disease, and ovarian cancer. Exposure of women to chemicals that are ovotoxic in laboratory animals (chemotherapeutic agents, contaminants of cigarette smoke) is known to be associated with early menopause. Therefore, an overall understanding of mechanisms involved in chemical-induced ovotoxicity is of general health-related concern (Hoyer and Sipes, 1996).


Ovarian Follicle Primordial Follicle Premature Ovarian Failure Preantral Follicle Mouse Ovary 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Patricia B. Hoyer
    • 1
  • Ellen A. Cannady
    • 2
  • Nicole A. Kroeger
    • 1
  • I. Glenn Sipes
    • 2
  1. 1.Department of PhysiologySouthwest Environmental Health Sciences Center The University of ArizonaUSA
  2. 2.Department of Pharmacology and ToxicologySouthwest Environmental Health Sciences Center The University of ArizonaUSA

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