Abstract
Acute influenza virus infection causes accumulation of reactive oxygen species (ROS) in target organs, initiating the processes of free radical lipid peroxidation (LPO) (Peterhanse 1997, Buffinton et al. 1992, Chetverikova et al. 1996). Rimantadine (Rim), (α-methyl-l-adamantil-methylamin hydrochlorid), a universal inhibitor of type A virus, is widely used in chemotherapeutic treatment and prevention of influenza. Rim interacts with the M-2 protein of the virus, inhibits its replication and blocks the formation of some replicative components of the influenza virus (Belshe et al. 1988, Zhiravetskii 1986). At present, it is not clear how Rim can affect the processes of LPO and drug metabolizing enzyme systems (DMES) during experimental influenza virus infection.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Belshe RB, Hall-Smith M, Hall CB, et. al., 1988, Genetic basis of resistance to rimantadine emergining during treatment of influenza virus infection. J. Virol., 62: 1508–1512
Buege JA, Aust SD, Microsomal lipid peroxidation. In: Methods in Enzymology. Fleisher S, Packer L (Eds). Academic Press: New York 1978, 65:302–310.
Buffinton GD, Christen S, Peterhans E, et. al. Oxidative stress in lungs of mice infected with influenza A virus. Free-Radic-Res-Commun. 1992, 16(2):99–110
Chetverikova LK, Inozemtseva LI Role of lipid peroxidation in the pathogenesis of the influenza and search for antiviral protective agents. Vestn Ross Acad Med Nauk 1996, 3:37–40.
Folch J et al. A simple method for the isolation and purification of total lipid from animal tissues. J Biol Chem 1957, 226: 497–507
Cherny VS, Lerche D, Markin VS, The effect of rimantadine on the structure of model and biological membranes, Gen Physiol. Biophys. 1989, 8(1), 23–37
Kharitonenkov JR, El-Karadaghi S, Fedorov AN et al. Effect of remantadine and amantadine on the interaction of influenza virus proteins with model lipid membranes. Vopr. Virusol. 1988, 33(1), 22–6
Mazel P et. al., Experiments illustrating drug metabolism in vitro-determination of microsomal aniline hydroxylase. In: Fundamentals of drug metabolism and drug disposition. La Du B.N., Mandel HG, Way EL(Eds). The Willkins Co: Baltimore 1971, 546–550.
Matsubara et al. Quantitative determination of cytochrome P-450 in rat liver homogenate, Anal. Biochem. 75, 596–603, 1976
Nash TJ, The colorimetric estimation of formaldehyde by means of the Hautch reaction. Biol. Chem. 1953, 5:, 416–22.
Peterhanse E, Reactive oxygen species and nitric oxide in viral diseases. Biol Trace Element Research 1997, 56: 107–115.
Recknagel R, Glende E, Spectrophotometric detection of lipid conjugated diens. Meth Enzymol 1984, 105: 331–337
Roering DL, Mascaro L Aust, S.D. Microsomal electron transport: Tetrafolium reduction by rat liver microsomal NADPH cytochrome C reductase. Arch Biochem 1972, 153: 475–9.
Zhiravetskii MM, Leont’eva MA, Vinograd JA et al. Mechanism of action of rim.hydrochl. on Sindbis virus reproduction: inhibition of virus penetration into the cell, Vopr Med Khim 1986, 32(6) 118–20
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Tantcheva, L., Pavlova, E., Savov, V., Galabov, A., Mileva, M., Braykova, A. (2001). Free Radical Lipid Peroxidation and Monooxygenase Activity in Experimental Influenza Virus Infection after Treatment with Rimantadine. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_30
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0667-6_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5185-6
Online ISBN: 978-1-4615-0667-6
eBook Packages: Springer Book Archive