Abstract
Haloalkanes, haloalkenes, and α-Haloacids are important industrial chemicals and environmental contaminants. For example, 1,2-dibromoethane and 1,2-dibromo-3-chloropropane were formerly used as fumigants and nematocides, trichloroethylene is a common environmental contaminant, and dichloroacetate (DCA), which is produced during the chlorination of drinking water, is present in finished drinking water supplies in the U.S. Many haloalkanes, haloalkenes, and α-haloacids are toxic, and some are rodent or suspected human carcinogens. The toxicity of these chemicals is associated with their bioactivation to reactive intermediates by the cytochromes P450 or glutathione transferases (GSTs).
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Anders, M.W. (2001). Formation and Fate of Reactive Intermediates of Haloalkanes, Haloalkenes, and α-Haloacids. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_12
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DOI: https://doi.org/10.1007/978-1-4615-0667-6_12
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