Abstract
A large number of animal studies and epidemiological studies which have been performed in the last decades has revealed that a number of selenium (Se)-containing compounds possess chemopreventive activity. In a meta-analysis from a number of studies comparing the significance of serum Se, retinol, beta-carotene and vitamin E, Se emerged as the factor with the most consistent protective effect (Comstock et al., 1992). On the other hand, geographic analysis and several prospective and case-control studies showed that people with low blood Se had an increased risk of cancer. Recently, a placebo-controlled double-blind study involving 1312 patients with a history in skin cancer showed a much lower prevalence of developing and dying from lung, colon or prostate cancer in the group receiving supplementation of 200 µg Se per day (Clark et al., 1996). A selenized yeast-extract was given to the people of this study. Relative risk of cancer incidence in lung, colon and prostate was reduced to 0.54 (P=0.04), 0.37 (P=0.002) and 0.42 (P=0.03), respectively. The Se-compounds responsible for the chemopreventive effect of selenized yeast still are not completely characterized yet. Selenomethionine accounts for 20% of the Se-containing compounds (Bird et al., 1997). Other compounds identified include selenocystine, Semethylselenocysteine and selenoethionine, representing approximately 20%. However, still 40-50% of the total Se is unidentified.
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Commandeur, J.N.M., Rooseboom, M., Vermeulen, N.P.E. (2001). Chemistry and Biological Activity of Novel Selenium-Containing Compounds. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_11
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DOI: https://doi.org/10.1007/978-1-4615-0667-6_11
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