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Biological Reactive Intermediates and Mechanisms of Cell Death

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Biological Reactive Intermediates VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 500))

Abstract

Apoptosis and necrosis are two modes of cell death with distinct morphological and biochemical features. Apoptosis is an active process characterized by cell shrinkage, nuclear and cytoplasmic condensation, chromatin fragmentation and phagocytosis. In contrast, necrosis is a passive form of cell death associated with inflammation resulting from cellular and organelle swelling, rupture of the plasma membrane and spilling of cellular contents into the intercellular milieu. Lethal levels of biological reactive intermediates may trigger either apoptotic or necrotic cell death, depending on the cell type and severity of insult. Further, effectuation of the apoptotic death program requires maintenance of a sufficient intracellular energy level and of a redox state compatible with caspase activity. Thus, ATP depletion or severe oxidative stress may redirect otherwise apoptotic cell death to necrosis.

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Authors and Affiliations

  1. Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, SE-171 77, Sweden

    John D. Robertson, Joya Chandra, Vladimir Gogvadze & Sten Orrenius

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  1. John D. Robertson
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  2. Joya Chandra
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  3. Vladimir Gogvadze
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  4. Sten Orrenius
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Editor information

Editors and Affiliations

  1. Université René Descartes, Paris, France

    Patrick M. Dansette

  2. Rutgers University and The Environmental & Occupational Health Sciences Institute, Piscataway, New Jersey, USA

    Robert Snyder

  3. CNRS, Paris, France

    Marcel Delaforge

  4. University of Surrey, Guildford, Surrey, England

    G. Gordon Gibson

  5. Institute of Toxicology and Environmental Health, The Technical University of Munich, Munich, Germany

    Helmut Greim

  6. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  7. University of Texas, Austin, Texas, USA

    Terrence J. Monks

  8. University of Arizona, Tucson, Arizona, USA

    I. Glenn Sipes

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Robertson, J.D., Chandra, J., Gogvadze, V., Orrenius, S. (2001). Biological Reactive Intermediates and Mechanisms of Cell Death. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_1

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  • DOI: https://doi.org/10.1007/978-1-4615-0667-6_1

  • Publisher Name: Springer, Boston, MA

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