Abstract
Osteoporosis is a bone disorder involving a decrease in bone mass and changes in the cancellous bone network leading to an increase in fracture risk. Until recently only bone mass and density were routinely assessed in patients, usually measured by dual-energy X-ray absorptiometry (DXA) or by quantitative computed tomography (QCT). Although bone mineral density (BMD) is an important determinant of bone strength, there is strong evidence that architecture of cancellous bone plays a significant role in bone strength and determines its biomechanical properties.1The importance of three-dimensional trabecular bone structure in osteoporosis increases when evaluating the response to therapy, as studies have reported that changes in fracture risk were not mainly attributable to BMD.2The measurement of both bone micro-architecture and BMD may improve the estimation of bone strength. However, the precise relationship between density, structure and mechanical properties is still under investigation.
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Laib, A., Beuf, O., Issever, A., Newitt, D.C., Majumdar, S. (2001). Direct Measures of Trabecular Bone Architecture from MR Images. In: Majumdar, S., Bay, B.K. (eds) Noninvasive Assessment of Trabecular Bone Architecture and the Competence of Bone. Advances in Experimental Medicine and Biology, vol 496. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0651-5_5
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DOI: https://doi.org/10.1007/978-1-4615-0651-5_5
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