Ectopeptidases pp 289-300 | Cite as

CD26/DPIV in Stress-induced, Cytokine-mediated Abortions

  • Martin Hildebrandt
  • Hans-Ulrich Demuth
  • Werner Reutter


Dipeptidyl Peptidase IV (DPIV, also known as DPIV or CD26) has a unique enzymatic activity, cleaving dipeptides from peptides and proteins carrying proline in their penultimate position, a feature which protects peptides from being digested by nonspecific proteases (Yaron and Naider, 1993). DPIV is associated with the plasma membrane of a variety of cells, including the venous portion of capillary endothelial cells (Mrazkowa et al 1986), hepatocytes (Kreisel et al 1984), enterocytes (Darmoul et al 1994) and cells of the renal glomeruli and proximal tubuli (Barth et al 1974). Expression of DPIV defines a higher degree of cell maturation and differentiation (Darmoul et al 1992). Organ-specific functions and regulatory circuits appear to have impact on DPIV expression, such as a proline-rich diet in the intestinal epithelium Suzuki et al 1993), γ-interferon in kidney (Stefanowicz et al 1993) and antigenic Schmitz et al 1996) or mitogenic (Plana et al 1991) stimulation of T lymphocytes.


Dipeptidyl Peptidase Proximal Tubuli Nonspecific Protease Human Glomerular Epithelial Cell Decisive Mediator 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Martin Hildebrandt
    • 1
  • Hans-Ulrich Demuth
    • 2
  • Werner Reutter
    • 3
  1. 1.Department of Internal Medicine-PsychosomaticsMedizinische Fakultät Charité der Humboldt-Universität zu BerlinGermany
  2. 2.probiodrug Gesellschaft für Arzneimittelforschung mbHHalle/ SGermany
  3. 3.Institut für Molekularbiologie und BiochemieFachbereich Humanmedizin der Freien Universität BerlinGermany

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