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Role of Non-Transferrin-Bound Iron in The Pathogenesis of Iron Overload and Toxicity

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Book cover Iron Chelation Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 509))

Abstract

Mammalian cells accumulate iron from two main circulating sources. The first one, which is the classical source, consists of iron bound to transferrin. The second one, identified by Hershko and colleagues1, is called Non-Transferrin-Bound Iron (NTBI). The latter source is increasingly acknowledged as being of primary importance in iron overload situations, due to its high uptake by parenchymal cells and its potential toxicity.

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  1. Service des Maladies du Foie et INSERM U-522, Pontchaillou University Hospital, Rennes, France

    Pierre Brissot

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  1. Pierre Brissot
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  2. Olivier Loréal
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  1. Hebrew University School of Medicine, Jerusalem, Israel

    Chaim Hershko

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Brissot, P., Loréal, O. (2002). Role of Non-Transferrin-Bound Iron in The Pathogenesis of Iron Overload and Toxicity. In: Hershko, C. (eds) Iron Chelation Therapy. Advances in Experimental Medicine and Biology, vol 509. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0593-8_3

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