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Animal Models of Hereditary Iron Transport Disorders

  • Chapter
Iron Chelation Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 509))

Abstract

Animal models have long been recognized to be useful in understanding disorders of human iron homeostasis. Although the advent of molecular biology has vastly improved our understanding of the biochemistry and cellular biology of iron transport, studies in testtubes and tissue culture cells cannot lead to a total understanding of human iron disorders. This is because human iron disorders are invariably abnormalities of iron balance, resulting from defects in regulation of intestinal iron absorption or inappropriate distribution of iron among the tissues of the body. Thus, molecular studies cannot replace animal models in this area.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Children’s Hospital and Harvard Medical School, Boston, MA, 02115

    Nancy C. Andrews

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  1. Nancy C. Andrews
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  1. Hebrew University School of Medicine, Jerusalem, Israel

    Chaim Hershko

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© 2002 Kluwer Academic/Plenum Publishers, New York

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Andrews, N.C. (2002). Animal Models of Hereditary Iron Transport Disorders. In: Hershko, C. (eds) Iron Chelation Therapy. Advances in Experimental Medicine and Biology, vol 509. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0593-8_1

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  • DOI: https://doi.org/10.1007/978-1-4615-0593-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46785-1

  • Online ISBN: 978-1-4615-0593-8

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