Variations in Neuropathology and Pathophysiology Over Time and Among Areas in a Rat Model of Focal Cerebral Ischemia
Immediately after occluding a cerebral artery, blood flow drops in the tissue perfused by that vessel. If perfusion is not restored shortly thereafter by collateral flow or opening the occluded artery, then brain cells become irreversibly injured and die. During and after middle cerebral artery (MCA) occlusion, the pattern of neuronal, glial, and microvascular damage and death appears to vary over time and among brain areas. Blood flow and blood-brain barrier (BBB) function may change with time and differ among brain areas and somehow be related to the ischemia-induced structural alterations, either driving the latter or resulting from them or both. In the present study, it is hypothesized and tested that there are significant differences both over time and in manifestation of ischemic damage among affected brain areas. If these possible variations prove to be real and significant, then stroke treatment may require combination therapy.
KeywordsMiddle Cerebral Artery Occlusion Preoptic Area Piriform Cortex Anterior Hypothalamus Local Cerebral Blood Flow
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