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Variations in Neuropathology and Pathophysiology Over Time and Among Areas in a Rat Model of Focal Cerebral Ischemia

  • Joseph Fenstermacher
  • Ling Wei
  • Kai-Feng Liu
  • Tavarekere Nagaraja
  • Kenneth Davies

Abstract

Immediately after occluding a cerebral artery, blood flow drops in the tissue perfused by that vessel. If perfusion is not restored shortly thereafter by collateral flow or opening the occluded artery, then brain cells become irreversibly injured and die. During and after middle cerebral artery (MCA) occlusion, the pattern of neuronal, glial, and microvascular damage and death appears to vary over time and among brain areas. Blood flow and blood-brain barrier (BBB) function may change with time and differ among brain areas and somehow be related to the ischemia-induced structural alterations, either driving the latter or resulting from them or both. In the present study, it is hypothesized and tested that there are significant differences both over time and in manifestation of ischemic damage among affected brain areas. If these possible variations prove to be real and significant, then stroke treatment may require combination therapy.

Keywords

Middle Cerebral Artery Occlusion Preoptic Area Piriform Cortex Anterior Hypothalamus Local Cerebral Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Joseph Fenstermacher
    • 1
  • Ling Wei
    • 1
    • 2
  • Kai-Feng Liu
    • 1
  • Tavarekere Nagaraja
    • 1
  • Kenneth Davies
    • 1
  1. 1.Department of AnesthesiologyHenry Ford HospitalDetroitUSA
  2. 2.Department of Neurology and NeurosurgeryWashington University School of MedicineSt. LouisUSA

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