Neuroprotective and Detoxifying Mechanisms at the Blood-Brain Interfaces

  • Jean-François Ghersi-Egea
  • Nathalie Strazielle
  • Marie-Françoise Belin


A fine homeostasis of the brain extracellular fluid is required for the neural cells to fulfill their complex physiological fonctions. This homeostasis is achieved and controlled by several mechanisms which primarily involve the specific features of the blood-brain interfaces (BBI). These interfaces include the cerebral capillaries forming the blood-brain barrier (BBB), and the choroid plexuses. The latter are located in the lateral, third and fourth ventricles and, together with the meningeal arachnoid, control the exchange processes between the blood and the cerebrospinal fluid (CSF). In addition, the continuous secretion, circulation and resorption of CSF, a circulatory system which is specific to the central nervous system, also participates in the maintenance of cerebral homeostasis.


Tight Junction Choroid Plexus Multidrug Resistance Associate Protein Reductive Metabolism Glia Limitans 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Jean-François Ghersi-Egea
    • 1
  • Nathalie Strazielle
    • 1
  • Marie-Françoise Belin
    • 1
  1. 1.Faculté de Médecine R.T.H. Laennec Rue G. ParadinINSERM U 433LyonFrance

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