Synthesis of Poly (Carboxyphenoxypropane-Sebacic Anhydride) for the Delivery of Drugs to the Brain

  • Abraham J. Domb
  • Michael Kubek


Bioerodible polymeric implants have been used for the delivery of a range of anticancer drugs [1–5]. These devices are favorable for clinical use because the device is eliminated from the brain after the drug has been depleted. Most studies have been conducted by Brem and co-workers using poly(l,3-p-carboxyphenoxypropane-sebacic acid) [P(CPP-SA)] as drug carrier [4–11].


Biodegradable Polymer Acetic Anhydride Sebacic Acid Dichloromethane Solution Fatty Acid Dimer 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Abraham J. Domb
    • 1
  • Michael Kubek
    • 2
  1. 1.Department of Medicinal Chemistry and Natural Products School of Pharmacy — Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Departments of Anatomy and Cell Biology, and PsychiatryIndianapolisUSA

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